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Literature summary extracted from

  • Sokolov, A.V.; Kostevich, V.A.; Kozlov, S.O.; Donskyi, I.S.; Vlasova, I.I.; Rudenko, A.O.; Zakharova, E.T.; Vasilyev, V.B.; Panasenko, O.M.
    Kinetic method for assaying the halogenating activity of myeloperoxidase based on reaction of celestine blue B with taurine halogenamines (2015), Free Radic. Res., 49, 777-789 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.2.2 4-aminobenzoic acid hydrazide
-
 Homo sapiens
1.11.2.2 catalase
-
 Homo sapiens
1.11.2.2 ceruloplasmin
-
 Homo sapiens
1.11.2.2 cysteine
-
 Homo sapiens
1.11.2.2 dapsone
-
 Homo sapiens
1.11.2.2 methionine
-
 Homo sapiens
1.11.2.2 NaN3
-
 Homo sapiens
1.11.2.2 NaSCN
-
 Homo sapiens
1.11.2.2 RPYLKVNPR
-
 Homo sapiens
1.11.2.2 Salicylhydroxamic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.2.2 Cl- + H2O2 + H+ Homo sapiens
-
 HClO + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.2.2 Homo sapiens P05164
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.2.2 heparin-Sepharose column chromatography, phenyl-agarose column chromatography, and Sephacryl S-200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.2.2 HL-60 cell
-
 Homo sapiens
-
1.11.2.2 leukocyte
-
 Homo sapiens
-
1.11.2.2 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.2.2 Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?
1.11.2.2 Cl- + H2O2 + H+ + taurine + H+
-
 Homo sapiens taurine monochloroamine + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.2.2 donor:H2O2 oxidoreductase
-
 Homo sapiens
1.11.2.2 MPO
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.11.2.2 0.000001
-
 at pH 6.0 and 25°C Homo sapiens catalase
1.11.2.2 0.00035
-
 at pH 6.0 and 25°C Homo sapiens ceruloplasmin
1.11.2.2 0.00058
-
 at pH 6.0 and 25°C Homo sapiens RPYLKVNPR
1.11.2.2 0.004
-
 at pH 6.0 and 25°C Homo sapiens 4-aminobenzoic acid hydrazide
1.11.2.2 0.007
-
 at pH 6.0 and 25°C Homo sapiens dapsone
1.11.2.2 0.021
-
 at pH 6.0 and 25°C Homo sapiens Salicylhydroxamic acid
1.11.2.2 0.025
-
 at pH 6.0 and 25°C Homo sapiens NaSCN
1.11.2.2 0.027
-
 at pH 6.0 and 25°C Homo sapiens cysteine
1.11.2.2 0.043
-
 at pH 6.0 and 25°C Homo sapiens methionine
1.11.2.2 0.055
-
 at pH 6.0 and 25°C Homo sapiens NaN3