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Literature summary extracted from

  • Bonaiuto, E.; Grancara, S.; Martinis, P.; Stringaro, A.; Colone, M.; Agostinelli, E.; Macone, A.; Stevanato, R.; Vianello, F.; Toninello, A.; Di Paolo, M.L.
    A novel enzyme with spermine oxidase properties in bovine liver mitochondria identification and kinetic characterization (2015), Free Radic. Biol. Med., 81, 88-99 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.16 N,N'-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL72527 Bos taurus
1.5.3.16 triethylenetetramine competitive inhibitor with spermine as substrate Bos taurus
1.5.3.17 N,N'-bis(2,3-butadienyl)-1,4-butanediamine i.e. MDL72527 Bos taurus
1.5.3.17 triethylenetetramine competitive inhibitor with spermine as substrate Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.16 0.211
-
 spermine pH 7.2, 37°C Bos taurus
1.5.3.16 1.898
-
 N,N'-bis(3-aminopropyl)ethylenediamine pH 7.2, 37°C Bos taurus
1.5.3.16 2.125
-
 N1-acetylspermine pH 7.2, 37°C Bos taurus
1.5.3.16 2.34
-
 spermidine pH 7.2, 37°C Bos taurus
1.5.3.17 0.211
-
 spermine pH 7.2, 37°C Bos taurus
1.5.3.17 1.898
-
 N,N'-bis(3-aminopropyl)ethylenediamine pH 7.2, 37°C Bos taurus
1.5.3.17 2.125
-
 N1-acetylspermine pH 7.2, 37°C Bos taurus
1.5.3.17 2.34
-
 spermidine pH 7.2, 37°C Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.3.16 mitochondrial matrix
-
 Bos taurus 5759
-
1.5.3.17 mitochondrial matrix
-
 Bos taurus 5759
-

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.16 Bos taurus
-
-
-
1.5.3.17 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.3.16 liver
-
 Bos taurus
-
1.5.3.17 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.16 N,N'-bis(3-aminopropyl)ethylenediamine + O2 + H2O
-
 Bos taurus ?
-
 ?
1.5.3.16 N1-acetylspermine + O2 + H2O
-
 Bos taurus ?
-
 ?
1.5.3.16 spermidine + O2 + H2O
-
 Bos taurus ?
-
 ?
1.5.3.16 spermine + O2 + H2O
-
 Bos taurus spermidine + 3-aminopropanal + H2O2
-
 ?
1.5.3.17 N,N'-bis(3-aminopropyl)ethylenediamine + O2 + H2O
-
 Bos taurus ?
-
 ?
1.5.3.17 N1-acetylspermine + O2 + H2O
-
 Bos taurus ?
-
 ?
1.5.3.17 spermidine + O2 + H2O
-
 Bos taurus ?
-
 ?
1.5.3.17 spermine + O2 + H2O
-
 Bos taurus spermidine + 3-aminopropanal + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.3.16 37
-
 assay at Bos taurus
1.5.3.17 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.3.16 7.2
-
 assay at Bos taurus
1.5.3.17 7.2
-
 assay at Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.3.16 0.172
-
 triethylenetetramine pH 7.2, 37°C, with spermine as substrate Bos taurus
1.5.3.17 0.172
-
 triethylenetetramine pH 7.2, 37°C, with spermine as substrate Bos taurus