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Literature summary extracted from

  • Greer, E.L.; Blanco, M.A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizabal-Corrales, D.; Hsu, C.H.; Aravind, L.; He, C.; Shi, Y.
    DNA methylation on N6-adenine in C. elegans (2015), Cell, 161, 868-878 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.72 expressed in Sf9 insect cells Caenorhabditis elegans

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.51 D186A inactive Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.51 N6-methyladenine in DNA + 2-oxoglutarate + O2 Caenorhabditis elegans
-
 adenine in DNA + formaldehyde + succinate + CO2
-
 ?
2.1.1.72 S-adenosyl-L-methionine + adenine in DNA Caenorhabditis elegans
-
 S-adenosyl-L-homocysteine + N6-methyladenine in DNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.51 Caenorhabditis elegans
-
 N2 Bristol
-
2.1.1.72 Caenorhabditis elegans
-
 N2 Bristol
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.51 N6-methyladenine in DNA + 2-oxoglutarate + O2
-
 Caenorhabditis elegans adenine in DNA + formaldehyde + succinate + CO2
-
 ?
2.1.1.72 S-adenosyl-L-methionine + adenine in DNA
-
 Caenorhabditis elegans S-adenosyl-L-homocysteine + N6-methyladenine in DNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.51 6mA DNA demethylase
-
 Caenorhabditis elegans
1.14.11.51 NMAD-1
-
 Caenorhabditis elegans
2.1.1.72 6mA DNA methyltransferases
-
 Caenorhabditis elegans
2.1.1.72 C18A3.1
-
 Caenorhabditis elegans
2.1.1.72 DAMT-1
-
 Caenorhabditis elegans
2.1.1.72 DNA N6 adenine methyltransferase 1
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
1.14.11.51 malfunction enzyme deletion accelerates the progressive fertility defect of spr-5 mutant worms Caenorhabditis elegans
2.1.1.72 malfunction enzyme deletion suppresses the trans-generational phenotypes of spr-5 mutant worms Caenorhabditis elegans