BRENDA - Enzyme Database show

Ligand binding phenomena that pertain to the metabolic function of renalase

Beaupre, B.A.; Roman, J.V.; Hoag, M.R.; Meneely, K.M.; Silvaggi, N.R.; Lamb, A.L.; Moran, G.R.; Arch. Biochem. Biophys. 612, 46-56 (2016)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.6.3.5
ADP
-
Pseudomonas savastanoi pv. phaseolicola
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.6.3.5
4-dihydronicotinamide mononucleotide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
4-dihydronicotinamide riboside
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
ADP
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
ADP-ribose
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
AMP
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
beta-NADP+
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
methyl nicotinamide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
nicotinamide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
nicotinamide mononucleotide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
nicotinamide riboside
-
Pseudomonas savastanoi pv. phaseolicola
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NADP+ + H2O2
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NADP+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NADP+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NADP+ + H2O2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.6.3.5
Pseudomonas savastanoi pv. phaseolicola
Q48MT7
-
-
1.6.3.5
Pseudomonas savastanoi pv. phaseolicola 1448A
Q48MT7
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
2-dihydronicotinamide adenine dinucleotide phosphate + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
2-dihydronicotinamide riboside + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
6-dihydronicotinamide adenine dinucleotide phosphate + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
6-dihydronicotinamide riboside + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
alpha-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
alpha-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
additional information
renalase exhibits a preference for substrates derived from beta-NAD+ over those derived from beta-NADP+
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
-
1.6.3.5
additional information
renalase exhibits a preference for substrates derived from beta-NAD+ over those derived from beta-NADP+
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
?
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.6.3.5
FAD
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
NADH
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
NADPH
-
Pseudomonas savastanoi pv. phaseolicola
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.6.3.5
ADP
-
Pseudomonas savastanoi pv. phaseolicola
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.6.3.5
FAD
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
NADH
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
NADPH
-
Pseudomonas savastanoi pv. phaseolicola
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.6.3.5
4-dihydronicotinamide mononucleotide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
4-dihydronicotinamide riboside
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
ADP
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
ADP-ribose
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
AMP
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
beta-NADP+
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
methyl nicotinamide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
nicotinamide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
nicotinamide mononucleotide
-
Pseudomonas savastanoi pv. phaseolicola
1.6.3.5
nicotinamide riboside
-
Pseudomonas savastanoi pv. phaseolicola
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NADP+ + H2O2
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NADP+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NAD+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola
-
beta-NADP+ + H2O2
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
Pseudomonas savastanoi pv. phaseolicola 1448A
-
beta-NADP+ + H2O2
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,2-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
1,2-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
1,6-dihydro-beta-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
2-dihydronicotinamide adenine dinucleotide phosphate + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
2-dihydronicotinamide riboside + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
6-dihydronicotinamide adenine dinucleotide phosphate + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
6-dihydronicotinamide riboside + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
?
1.6.3.5
alpha-NADH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NAD+ + H2O2
-
-
-
?
1.6.3.5
alpha-NADPH + H+ + O2
-
741785
Pseudomonas savastanoi pv. phaseolicola
beta-NADP+ + H2O2
-
-
-
?
1.6.3.5
additional information
renalase exhibits a preference for substrates derived from beta-NAD+ over those derived from beta-NADP+
741785
Pseudomonas savastanoi pv. phaseolicola
?
-
-
-
-
1.6.3.5
additional information
renalase exhibits a preference for substrates derived from beta-NAD+ over those derived from beta-NADP+
741785
Pseudomonas savastanoi pv. phaseolicola 1448A
?
-
-
-
-