Literature summary extracted from

Zhang, X.; Qu, Y.; Ma, Q.; Kong, C.; Zhou, H.; Cao, X.; Shen, W.; Shen, E.; Zhou, J.
Production of indirubin from tryptophan by recombinant Escherichia coli containing naphthalene dioxygenase genes from Comamonas sp. MQ (2014), Appl. Biochem. Biotechnol., 172, 3194-3206 .

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.12.12	expressed in Escherichia coli BL21(DE3) cells	Comamonas sp. MQ

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.12.12	naphthalene + NADH + H+ + O2	Comamonas sp. MQ	-	(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.12.12	Comamonas sp. MQ	G9IE62	large subunit	-
1.14.12.12	Comamonas sp. MQ	G9IE63	small subunit	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.12.12	indole + NADH + H+ + O2	-	Comamonas sp. MQ	cis-indole-2,3-dihydrodiol + NAD+	-	?
1.14.12.12	naphthalene + NADH + H+ + O2	-	Comamonas sp. MQ	(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.12.12	NAG	-	Comamonas sp. MQ
1.14.12.12	NDO	-	Comamonas sp. MQ

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.12.12	NADH	-	Comamonas sp. MQ

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Release 2023.1 (January 2023)