EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.19 | 2,2-dimethyl-4-propionylaminobutanal | causes substrate inhibition at high concentration | Pisum sativum | |
1.2.1.19 | 3-methyl-3-butyrylaminopropanal | causes substrate inhibition at high concentration | Pisum sativum | |
1.2.1.19 | 3-methyl-4-butyrylaminobutanal | causes substrate inhibition at high concentration | Pisum sativum | |
1.2.1.19 | 3-propionylaminopropanal | causes substrate inhibition at high concentration | Pisum sativum | |
1.2.1.19 | 4-acetamidobutanal | causes substrate inhibition at high concentration | Pisum sativum | |
1.2.1.19 | 4-propionylaminobutanal | causes substrate inhibition at high concentration | Pisum sativum | |
1.2.1.19 | additional information | isozyme PsAMADH 1 shows no substrate inhibition | Pisum sativum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.19 | 0.00727 | - |
3-aminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.0392 | - |
3-adipylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.0459 | - |
4-aminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.0651 | - |
3-propionylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.0718 | - |
3-aminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.0927 | - |
4-propionylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.0935 | - |
2-methyl-3-propionylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.109 | - |
3-acetaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.12 | - |
3-valerylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.13 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.137 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.153 | - |
4-aminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.183 | - |
2-methyl-3-propionylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.189 | - |
2-methyl-4-propionylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.226 | - |
3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.227 | - |
3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.242 | - |
4-acetaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.264 | - |
4-butyrylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.266 | - |
2,2-dimethyl-3-propionylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.268 | - |
3-acetaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.271 | - |
3-valerylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.304 | - |
4-valerylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.327 | - |
4-propionylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.361 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.366 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.397 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.431 | - |
3-adipylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.469 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.477 | - |
2,2-dimethyl-3-propionylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.49 | 2 | 3-propionylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.506 | - |
2,2-dimethyl-4-propionylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.516 | - |
4-acetaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.525 | - |
2-methyl-4-propionylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.531 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.629 | - |
4-valerylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.638 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 0.738 | - |
4-butyrylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.42 | - |
2,2-dimethyl-4-aminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.19 | 3-aminopropanal + NAD+ + H2O | Pisum sativum | - |
3-aminopropanoate + NADH + H+ | - |
? | |
1.2.1.19 | 4-aminobutanal + NAD+ + H2O | Pisum sativum | - |
4-aminobutanoate + NADH + 2 H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.19 | Pisum sativum | Q8VWZ1 | - |
- |
1.2.1.19 | Pisum sativum | Q93YB2 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.19 | 2,2-dimethyl-3-propionylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 2,2-dimethyl-3-propionylaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 2,2-dimethyl-4-aminobutanal + NAD+ + H2O | - |
Pisum sativum | 2,2-dimethyl-4-aminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 2,2-dimethyl-4-propionylaminobutanal + NAD+ + H2O | - |
Pisum sativum | 2,2-dimethyl-4-propionylaminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 2-methyl-3-butyrylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 2-methyl-3-butyrylaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 2-methyl-3-propionylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 2-methyl-3-propionylaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 2-methyl-4-aminobutanal + NAD+ + H2O | - |
Pisum sativum | 2-methyl-4-aminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 2-methyl-4-propionylaminobutanal + NAD+ + H2O | - |
Pisum sativum | 2-methyl-4-propionylaminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 3-acetaminopropanal + NAD+ + H2O | - |
Pisum sativum | 3-acetaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 3-adipylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 3-adipylaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 3-aminopropanal + NAD+ + H2O | - |
Pisum sativum | 3-aminopropanoate + NADH + H+ | - |
? | |
1.2.1.19 | 3-butyrylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 3-butyrylaminpropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 3-methyl-3-butyrylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 3-methyl-3-butyrylaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 3-methyl-4-aminobutanal + NAD+ + H2O | - |
Pisum sativum | 3-methyl-4-aminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 3-propionylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 3-propionylaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 3-valerylaminopropanal + NAD+ + H2O | - |
Pisum sativum | 3-valerylaminopropanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 4-acetaminobutanal + NAD+ + H2O | - |
Pisum sativum | 4-acetaminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 4-aminobutanal + NAD+ + H2O | - |
Pisum sativum | 4-aminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 4-butyrylaminobutanal + NAD+ + H2O | - |
Pisum sativum | 4-butyrylaminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 4-propionylaminobutanal + NAD+ + H2O | - |
Pisum sativum | 4-propionylaminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | 4-valerylaminobutanal + NAD+ + H2O | - |
Pisum sativum | 4-valerylaminobutanoate + NADH + 2 H+ | - |
? | |
1.2.1.19 | additional information | design and synthesis of N-acyl derivates of 3-aminopropanal and 4-aminobutanal and confirmed as substrates of AMADH isoenzyme PsAMADH 1, molecular docking indicates the possible auxiliary role of Tyr163, Ser295 and Gln451 in binding of the substrates. Substrate specificity and molecular docking, overview. The substrate properties of N-acyl-omega-aminoaldehydes arise from their proper binding at the active site, which is facilitated by interactions with amino acid residues in the substrate channel such as Tyr163 | Pisum sativum | ? | - |
? | |
1.2.1.19 | additional information | design and synthesis of N-acyl derivates of 3-aminopropanal and 4-aminobutanal and confirmed as substrates of AMADH isoenzyme PsAMADH 2, molecular docking indicates the possible auxiliary role of Tyr163, Ser295 and Gln451 in binding of the substrates. Substrate specificity and molecular docking, overview. The substrate properties of N-acyl-omega-aminoaldehydes arise from their proper binding at the active site, which is facilitated by interactions with amino acid residues in the substrate channel such as Tyr163 | Pisum sativum | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.19 | 4-aminobutyraldehyde dehydrogenase | - |
Pisum sativum |
1.2.1.19 | ABALDH | - |
Pisum sativum |
1.2.1.19 | AMADH | - |
Pisum sativum |
1.2.1.19 | aminoaldehyde dehydrogenase | - |
Pisum sativum |
1.2.1.19 | PsAMADH 1 | - |
Pisum sativum |
1.2.1.19 | PsAMADH 2 | - |
Pisum sativum |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.2.1.19 | 30 | - |
assay at | Pisum sativum |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.19 | 1.03 | - |
3-adipylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.05 | - |
4-valerylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.2 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.22 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.24 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.39 | - |
4-butyrylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.41 | - |
2,2-dimethyl-3-propionylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.56 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.6 | - |
4-butyrylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.63 | - |
4-propionylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.65 | - |
4-propionylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 1.93 | - |
4-valerylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 2.02 | - |
3-valerylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 2.03 | - |
2-methyl-3-propionylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 2.32 | - |
2-methyl-4-propionylaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 2.41 | - |
3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 2.49 | - |
4-acetaminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 2.84 | - |
4-acetaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 2.87 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 3.02 | - |
4-aminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 3.1 | - |
4-aminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 3.2 | - |
2,2-dimethyl-4-aminobutanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 3.4 | - |
3-propionylaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 3.61 | - |
3-acetaminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 3.65 | - |
3-aminopropanal | isozyme PsAMADH 1, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 4.08 | - |
2-methyl-4-propionylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 5.8 | - |
2,2-dimethyl-4-propionylaminobutanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 6.49 | - |
2-methyl-3-propionylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 6.84 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 7.72 | - |
3-propionylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 8.13 | - |
3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 8.78 | - |
3-adipylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 9.42 | - |
3-aminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 9.54 | - |
3-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 11 | - |
3-valerylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 12.1 | - |
2-methyl-3-butyrylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 13.9 | - |
3-acetaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum | |
1.2.1.19 | 14.4 | - |
2,2-dimethyl-3-propionylaminopropanal | isozyme PsAMADH 2, pH 9.0, 30°C | Pisum sativum |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.19 | 9 | - |
assay at | Pisum sativum |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.19 | NAD+ | - |
Pisum sativum |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.2.1.19 | evolution | the enzyme is a member of the aldehyde dehydrogenase 10 family | Pisum sativum |