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Literature summary extracted from

  • O'Brien, L.; Hosick, P.A.; John, K.; Stec, D.E.; Hinds, T.D.
    Biliverdin reductase isozymes in metabolism (2015), Trends Endocrinol. Metab., 26, 212-220.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 biliverdin IXalpha + NADH + H+ Homo sapiens substrate for isoform BVRA bilirubin IXalpha + NAD+
-
 r
1.3.1.24 biliverdin IXalpha + NADPH + H+ Homo sapiens substrate for isoform BVRA bilirubin IXalpha + NADP+
-
 r
1.3.1.24 biliverdin IXbeta + NADH + H+ Homo sapiens substrate for isoform BVRB bilirubin IXbeta + NAD+
-
 r
1.3.1.24 biliverdin IXbeta + NADPH + H+ Homo sapiens substrate for isoform BVRB bilirubin IXbeta + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens P30043
-
-
1.3.1.24 Homo sapiens P53004
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.24 brain
-
 Homo sapiens
-
1.3.1.24 liver
-
 Homo sapiens
-
1.3.1.24 lung
-
 Homo sapiens
-
1.3.1.24 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 biliverdin IXalpha + NADH + H+ substrate for isoform BVRA Homo sapiens bilirubin IXalpha + NAD+
-
 r
1.3.1.24 biliverdin IXalpha + NADPH + H+ substrate for isoform BVRA Homo sapiens bilirubin IXalpha + NADP+
-
 r
1.3.1.24 biliverdin IXbeta + NADH + H+ substrate for isoform BVRB Homo sapiens bilirubin IXbeta + NAD+
-
 r
1.3.1.24 biliverdin IXbeta + NADPH + H+ substrate for isoform BVRB Homo sapiens bilirubin IXbeta + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 BVRA isoform Homo sapiens
1.3.1.24 BVRB isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.3.1.24 metabolism isoform BVRA interacts with components in both the PI3-kinase/Akt and the IRK/IRS/PI3-kinase/MAPK pathyway Homo sapiens
1.3.1.24 physiological function the enzyme protects against glucose intolerance and diabetes by affecting the pancreatic islet. Isoform BVRA enhances protein kinase CbetaII localization at the cellular membrane and also modulates protein kinase Cdelta and protein kinase Czeta Homo sapiens