Literature summary extracted from

Kollerov, V.V.; Lobastova, T.G.; Monti, D.; Deshcherevskaya, N.O.; Ferrandi, E.E.; Fronza, G.; Riva, S.; Donova, M.V.
Deoxycholic acid transformations catalyzed by selected filamentous fungi (2016), Steroids, 107, 20-29.

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.176	Curvularia lunata	-	-	-
1.1.1.176	Curvularia lunata VKM F-644	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.176	deoxycholate + NADP+	3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid	Curvularia lunata	12-oxo-lithocholic acid + NADPH + H+	i.e. 3alpha-hydroxy-12-oxo-5beta-cholan-24-oic acid	?
1.1.1.176	deoxycholate + NADP+	3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid	Curvularia lunata VKM F-644	12-oxo-lithocholic acid + NADPH + H+	i.e. 3alpha-hydroxy-12-oxo-5beta-cholan-24-oic acid	?
1.1.1.176	additional information	reaction product analysis confirmed by MS and NMR analyses	Curvularia lunata	?	-	?
1.1.1.176	additional information	reaction product analysis confirmed by MS and NMR analyses	Curvularia lunata VKM F-644	?	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.176	NADP+	-	Curvularia lunata

General Information

EC Number	General Information	Comment	Organism
1.1.1.176	additional information	deoxycholic acid transformation by fungal strains, detailed overview. Identification of several strains capable of producing cholic acid, ursocholic acid, 12-oxo-lithocholic acid, and 3-oxo-deoxycholic acid as major products from deoxycholic acid	Curvularia lunata

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Release 2023.1 (January 2023)