Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Perret, A.; Lechaplais, C.; Tricot, S.; Perchat, N.; Vergne, C.; Pelle, C.; Bastard, K.; Kreimeyer, A.; Vallenet, D.; Zaparucha, A.; Weissenbach, J.; Salanoubat, M.
    A novel acyl-CoA beta-transaminase characterized from a metagenome (2011), PLoS ONE, 6, e22918.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.111 0.0043
-
 (3S)-3-aminobutanoyl-CoA pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans
2.6.1.111 2.9
-
 2-oxoglutarate pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans
2.6.1.111 20.1
-
 pyruvate pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.111 93000
-
 gel fitlration Candidatus Cloacimonas acidaminovorans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.111 (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate Candidatus Cloacimonas acidaminovorans
-
 acetoacetyl-CoA + L-glutamate
-
 ?
2.6.1.111 (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate Candidatus Cloacimonas acidaminovorans Evry
-
 acetoacetyl-CoA + L-glutamate
-
 ?
2.6.1.111 (3S)-3-aminobutanoyl-CoA + pyruvate Candidatus Cloacimonas acidaminovorans
-
 acetoacetyl-CoA + L-alanine
-
 ?
2.6.1.111 (3S)-3-aminobutanoyl-CoA + pyruvate Candidatus Cloacimonas acidaminovorans Evry
-
 acetoacetyl-CoA + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.111 Candidatus Cloacimonas acidaminovorans B0VH76
-
-
2.6.1.111 Candidatus Cloacimonas acidaminovorans Evry B0VH76
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.111 (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
-
 Candidatus Cloacimonas acidaminovorans acetoacetyl-CoA + L-glutamate
-
 ?
2.6.1.111 (3S)-3-aminobutanoyl-CoA + 2-oxoglutarate
-
 Candidatus Cloacimonas acidaminovorans Evry acetoacetyl-CoA + L-glutamate
-
 ?
2.6.1.111 (3S)-3-aminobutanoyl-CoA + pyruvate
-
 Candidatus Cloacimonas acidaminovorans acetoacetyl-CoA + L-alanine
-
 ?
2.6.1.111 (3S)-3-aminobutanoyl-CoA + pyruvate
-
 Candidatus Cloacimonas acidaminovorans Evry acetoacetyl-CoA + L-alanine
-
 ?
2.6.1.111 S-[2-(acetylamino)ethyl] 3-amino-3-phenylpropanethioate + 2-oxoglutarate i.e. beta-phenylalanine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat Candidatus Cloacimonas acidaminovorans S-[2-(acetylamino)ethyl] 3-oxo-3-phenylpropanethioate + L-glutamate
-
 ?
2.6.1.111 S-[2-(acetylamino)ethyl] 3-amino-3-phenylpropanethioate + 2-oxoglutarate i.e. beta-phenylalanine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat Candidatus Cloacimonas acidaminovorans Evry S-[2-(acetylamino)ethyl] 3-oxo-3-phenylpropanethioate + L-glutamate
-
 ?
2.6.1.111 S-[2-(acetylamino)ethyl] 3-amino-5-methylhexanethioate + 2-oxoglutarate i.e. beta-homoleucine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat Candidatus Cloacimonas acidaminovorans S-[2-(acetylamino)ethyl] 3-oxo-5-methylhexanethioate + L-glutamate
-
 ?
2.6.1.111 S-[2-(acetylamino)ethyl] 3-amino-5-methylhexanethioate + 2-oxoglutarate i.e. beta-homoleucine-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat Candidatus Cloacimonas acidaminovorans Evry S-[2-(acetylamino)ethyl] 3-oxo-5-methylhexanethioate + L-glutamate
-
 ?
2.6.1.111 S-[2-(acetylamino)ethyl] 3-aminobutanethioate + 2-oxoglutarate i.e. 3-aminobutanoyl-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat Candidatus Cloacimonas acidaminovorans S-[2-(acetylamino)ethyl] 3-oxobutanethioate + L-glutamate
-
 ?
2.6.1.111 S-[2-(acetylamino)ethyl] 3-aminobutanethioate + 2-oxoglutarate i.e. 3-aminobutanoyl-S-(N-acetylcysteamine), N-acetylcysteamine can serve as a CoA mimic for Kat Candidatus Cloacimonas acidaminovorans Evry S-[2-(acetylamino)ethyl] 3-oxobutanethioate + L-glutamate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.6.1.111 dimer 2 * 46481, calculated Candidatus Cloacimonas acidaminovorans

Synonyms

EC Number Synonyms Comment Organism
2.6.1.111 3-aminobutyryl-CoA aminotransferase
-
 Candidatus Cloacimonas acidaminovorans
2.6.1.111 acyl-CoA beta-transaminase
-
 Candidatus Cloacimonas acidaminovorans
2.6.1.111 KAT
-
 Candidatus Cloacimonas acidaminovorans

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.111 30
-
-
 Candidatus Cloacimonas acidaminovorans

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.6.1.111 33
-
 complete loss of activity above Candidatus Cloacimonas acidaminovorans

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.111 0.4
-
 pyruvate pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans
2.6.1.111 1.8
-
 2-oxoglutarate pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans
2.6.1.111 1.8
-
 (3S)-3-aminobutanoyl-CoA pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.111 8
-
-
 Candidatus Cloacimonas acidaminovorans

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.111 7
-
 inactive below Candidatus Cloacimonas acidaminovorans
2.6.1.111 7.5 8.5 narrow Candidatus Cloacimonas acidaminovorans
2.6.1.111 10
-
 20% of maximum activity Candidatus Cloacimonas acidaminovorans

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.111 pyridoxal 5'-phosphate
-
 Candidatus Cloacimonas acidaminovorans

General Information

EC Number General Information Comment Organism
2.6.1.111 physiological function gene product Kat may participate in an alternative pathway of lysine fermentation Candidatus Cloacimonas acidaminovorans

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.6.1.111 0.02
-
 pyruvate pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans
2.6.1.111 0.62
-
 2-oxoglutarate pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans
2.6.1.111 420
-
 (3S)-3-aminobutanoyl-CoA pH 8.1, 28°C Candidatus Cloacimonas acidaminovorans