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Literature summary extracted from

  • Schmidt, M.; Straub, R.H.
    11beta-Hydroxysteroid dehydrogenase enzymes modulate effects of glucocorticoids in rheumatoid arthritis synovial cells (2015), Neuroimmunomodulation, 22, 40-45.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisol + NADP+ Homo sapiens substrate for isoforms 11betaHSD1 and 11betaHSD2 cortisone + NADPH + H+
-
 ?
1.1.1.146 cortisone + NADPH + H+ Homo sapiens substrate for isoform 11betaHSD1 only cortisol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 fibroblast isoform 11betaHSD1 Homo sapiens
-
1.1.1.146 lymphocyte isoform 11betaHSD2 Homo sapiens
-
1.1.1.146 macrophage isoform 11betaHSD2 Homo sapiens
-
1.1.1.146 osteoblast isoform 11betaHSD1 Homo sapiens
-
1.1.1.146 synovial tissue
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NADP+ substrate for isoforms 11betaHSD1 and 11betaHSD2 Homo sapiens cortisone + NADPH + H+
-
 ?
1.1.1.146 cortisone + NADPH + H+ substrate for isoform 11betaHSD1 only Homo sapiens cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.146 11betaHSD1 isoform Homo sapiens
1.1.1.146 11betaHSD2 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.146 Homo sapiens the enzyme is upregulated in rheumatoid arthritis up