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Literature summary extracted from

  • Lin, R.; Elf, S.; Shan, C.; Kang, H.B.; Ji, Q.; Zhou, L.; Hitosugi, T.; Zhang, L.; Zhang, S.; Seo, J.H.; Xie, J.; Tucker, M.; Gu, T.L.; Sudderth, J.; Jiang, L.; Mitsche, M.; DeBerardinis, R.J.; Wu, S.; Li, Y.; Mao, H.; Chen, P.R.; Wang, D.; Chen, G.Z.; Hurwitz, S.J.; Lonial, S.; Arellano, M.L.; Khoury, H.J.; Khuri, F.R.
    6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling (2015), Nat. Cell Biol., 17, 1484-1496.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Homo sapiens
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 212LN cell
-
 Homo sapiens
-
1.1.1.44 H-1299 cell
-
 Homo sapiens
-
1.1.1.44 H-157 cell
-
 Homo sapiens
-
1.1.1.44 H-322 cell
-
 Homo sapiens
-
1.1.1.44 HaCaT cell
-
 Homo sapiens
-
1.1.1.44 K-562 cell
-
 Homo sapiens
-
1.1.1.44 MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Homo sapiens D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Homo sapiens
1.1.1.44 6PGD
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+ dependent on Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.44 malfunction enzyme suppression decreases lipogenesis and RNA biosynthesis and elevates reactive oxygen species levels in cancer cells, attenuating cell proliferation and tumor growth Homo sapiens
1.1.1.44 metabolism enzyme-mediated production of D-ribulose 5-phosphate inhibits adenine monophosphate-activated protein kinase activation by disrupting the active tumor suppressor liver kinase B1 complex, thereby activating acetyl-CoA carboxylase 1 and lipogenesis Homo sapiens
1.1.1.44 physiological function the enzyme is important for oxidative triphosphate and lipogenesis, as well as proliferative and tumor growth potential of cancer cells Homo sapiens