Literature summary extracted from

Kim, H.; Lee, H.; Lim, K.; Surh, Y.; Na, H.
15-Deoxy-DELTA12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells (2014), Mutat. Res., 768, 6-15.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.141	prostaglandin E2 + NAD+	Homo sapiens	-	15-oxoprostaglandin E2 + NADH + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.141	Homo sapiens	P15428	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.141	MDA-MB-231 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.141	prostaglandin E2 + NAD+	-	Homo sapiens	15-oxoprostaglandin E2 + NADH + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.141	15-PGDH	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.141	NAD+	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
1.1.1.141	Homo sapiens	15-deoxy-DELTA(12,14)-prostaglandin J2 upregulates the expression and the activity of the enzyme through reactive oxygen species-mediated activation of extracellular-signal related kinase1/2 and subsequently Elk-1 in human breast cancer MDA-MB-231 cells	up

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Release 2023.1 (January 2023)