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Literature summary extracted from

  • Abekhoukh, S.; Planque, C.; Ripoll, C.; Urbaniak, P.; Paul, J.-L.; Delabar, J.-M.; Janel, N.
    Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice (2013), Mol. Neurobiol., 47, 105-116.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.12.1 gene DYRK1A, quantitative expression analysis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.12.1 harmine
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.12.1 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.1 ATP + a protein Mus musculus
-
 ADP + a phosphoprotein
-
 ?
2.7.12.1 ATP + extracellular MAP kinase kinase Mus musculus
-
 ADP + phospho-[MAP kinase kinase]
-
 ?
2.7.12.1 ATP + extracellular signal-regulated kinase Mus musculus
-
 ADP + phospho-[extracellular signal-regulated kinase]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.1 Mus musculus Q61214
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.1 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.1 ATP + a protein
-
 Mus musculus ADP + a phosphoprotein
-
 ?
2.7.12.1 ATP + extracellular MAP kinase kinase
-
 Mus musculus ADP + phospho-[MAP kinase kinase]
-
 ?
2.7.12.1 ATP + extracellular signal-regulated kinase
-
 Mus musculus ADP + phospho-[extracellular signal-regulated kinase]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.1 DYRK1A
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.12.1 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.12.1 malfunction Dyrk1A expression is increased in the brain of cystathionine-beta-synthase (CBS)-deficient mice. The murine model of hyperhomocysteinemia shows an activation of extracellular signal-regulated kinase (ERK) pathway. Significant increase of phosphorylated ERK, phosphorylated MAP kinase kinases, and phosphorylated Akt in the brain of CBS-deficient and Dyrk1A-overexpressing mice. Interaction between Dyrk1A and Grb2 is increased in the brain of Dyrk1A transgenic mice, but Dyrk1A overexpression results in decreased interaction of sprouty 2 and Grb2, and in increased receptor tyrosine kinases phosphorylation and activation, overview Mus musculus
2.7.12.1 physiological function Dyrk1A is involved in diverse functions ranging from development and growth to apoptosis Mus musculus