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Literature summary extracted from

  • Manhas, R.; Anand, S.; Tripathi, P.; Madhubala, R.
    Deletion of vitamin C biosynthesis enzyme, arabino-1, 4-lactone oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells (2014), Mol. Microbiol., 91, 1227-1239.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.37 D-arabinono-1,4-lactone + O2 Leishmania donovani
-
 dehydro-D-arabinono-1,4-lactone + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.37 Leishmania donovani
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.37 promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.37 D-arabinono-1,4-lactone + O2
-
 Leishmania donovani dehydro-D-arabinono-1,4-lactone + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.3.37 ALO
-
 Leishmania donovani
1.1.3.37 arabino-1,4-lactone oxidase
-
 Leishmania donovani

General Information

EC Number General Information Comment Organism
1.1.3.37 malfunction enzyme deletion in Leishmania donovani results in increased pro-inflammatory responses from host immune cells. Enzyme null mutant parasites show growth defect and loss in virulence Leishmania donovani
1.1.3.37 metabolism the enzyme catalyses the last step in ascorbate biosynthesis pathway Leishmania donovani