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Literature summary extracted from

  • Polevoda, B.; Hoskins, J.; Sherman, F.
    Properties of Nat4, an Nalpha-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4 (2009), Mol. Cell. Biol., 29, 2913-2924.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.257 ribosome
-
 Saccharomyces cerevisiae 5840
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H2A] Saccharomyces cerevisiae
-
 an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
 ?
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H2A] Saccharomyces cerevisiae B-15329
-
 an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
 ?
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H4] Saccharomyces cerevisiae efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4 an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
 ?
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H4] Saccharomyces cerevisiae B-15329 efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4 an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Arg-Gly Saccharomyces cerevisiae
-
 acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Arg-Gly Saccharomyces cerevisiae B-15329
-
 acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Gly-Lys Saccharomyces cerevisiae
-
 acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Gly-Lys Saccharomyces cerevisiae B-15329
-
 acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.257 Saccharomyces cerevisiae
-
-
-
2.3.1.257 Saccharomyces cerevisiae B-15329
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.257
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
-
 Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
 ?
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
-
 Saccharomyces cerevisiae B-15329 an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
 ?
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H4] efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4 Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
 ?
2.3.1.257 acetyl-CoA + an N-terminal-L-seryl-[histone H4] efficient acetylation requires at least 30 to 50 amino acid residues of the N terminus of histone H4 Saccharomyces cerevisiae B-15329 an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Arg-Gly
-
 Saccharomyces cerevisiae acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Arg-Gly
-
 Saccharomyces cerevisiae B-15329 acetyl-CoA + Nalpha-acetyl-Ser-Gly-Arg-Lys
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Gly-Lys
-
 Saccharomyces cerevisiae acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys
-
 ?
2.3.1.257 acetyl-CoA + Ser-Gly-Gly-Lys
-
 Saccharomyces cerevisiae B-15329 acetyl-CoA + Nalpha-acetyl-Ser-Gly-Gly-Lys
-
 ?
2.3.1.257 additional information the enzyme does not acetylate histone H3, adrenocorticotropin, and an altered iso-1-cytochrome c protein with short NatD type N termini (SGGKGGKA) Saccharomyces cerevisiae ?
-
 ?
2.3.1.257 additional information the enzyme does not acetylate histone H3, adrenocorticotropin, and an altered iso-1-cytochrome c protein with short NatD type N termini (SGGKGGKA) Saccharomyces cerevisiae B-15329 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.257 NAT4 catalytic subunit of NAtD Saccharomyces cerevisiae
2.3.1.257 NatD
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.3.1.257 malfunction enzyme depletion strains show several minor phenotypes, including sensitivity to 3-aminotriazole, benomyl, and thiabendazole Saccharomyces cerevisiae