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Literature summary extracted from

  • Sandoval, J.M.; Arenas, F.A.; Garcia, J.A.; Diaz-Vasquez, W.A.; Valdivia-Gonzalez, M.; Sabotier, M.; Vasquez, C.C.
    Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner (2015), Microbiol. Res., 177, 22-27.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.44 menadione the enzyme shows more than 4fold increased activity at 2.5 mM menadione Escherichia coli
1.1.1.44 tellurite the enzyme shows more than 4fold increased activity at 0.005 mg/ml tellurite Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.44 50000
-
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Escherichia coli
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
1.1.1.44 6-phospho-D-gluconate + NADP+ Escherichia coli BW25113
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Escherichia coli
-
-
-
1.1.1.44 Escherichia coli BW25113
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Escherichia coli D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Escherichia coli BW25113 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.44 ? x * 50000, His6-tagged enzyme, SDS-PAGE Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Escherichia coli
1.1.1.44 gnd
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+ dependent on Escherichia coli

General Information

EC Number General Information Comment Organism
1.1.1.44 physiological function the enzyme is involved in tellurite detoxification and resistance in Escherichia coli Escherichia coli