BRENDA - Enzyme Database

Liposomes modified with cardiolipin can act as a platform to regulate the potential flux of NADP

Suga, K.; Hamasaki, A.; Chinzaka, J.; Umakoshi, H.; Metab. Eng. Commun. 3, 8-14 (2016)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.42
liposome
ICDH activity is enhanced with liposomes at 5 mol% cardiolipin, but inhibited at 30 mol% cardiolipin. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes did not affect the activity of ICDH
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
liposome
ICDH activity is enhanced with liposomes at 5 mol% cardiolipin, but inhibited at 30 mol% cardiolipin. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes do not affect the activity of ICDH
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Homo sapiens
-
2-oxoglutarate + CO2 + NADPH + H+
-
-
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
740946
Homo sapiens
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.42
37
-
assay at
Homo sapiens
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.42
7.3
-
assay at
Homo sapiens
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Homo sapiens
1.1.1.42
NADPH
-
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.1.1.42
liposome
ICDH activity is enhanced with liposomes at 5 mol% cardiolipin, but inhibited at 30 mol% cardiolipin. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes did not affect the activity of ICDH
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Homo sapiens
1.1.1.42
NADPH
-
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.1.1.42
liposome
ICDH activity is enhanced with liposomes at 5 mol% cardiolipin, but inhibited at 30 mol% cardiolipin. 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine liposomes do not affect the activity of ICDH
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Homo sapiens
-
2-oxoglutarate + CO2 + NADPH + H+
-
-
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
740946
Homo sapiens
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
1.1.1.42
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.1.1.42
7.3
-
assay at
Homo sapiens
General Information
EC Number
General Information
Commentary
Organism
1.1.1.42
physiological function
membranes in cardiolipin-modified liposomes are dehydrated by ICDH binding. Liposomes induce a conformational change in ICDH, indicating that cardiolipin-rich membrane domains can inhibit ICDH activity. Lipid membranes, including cardiolipin molecules, can act as a platform to regulate ICDH-related metabolic pathways such as the tricarboxylic acid cycle and lipid synthesis
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.1.1.42
physiological function
membranes in cardiolipin-modified liposomes are dehydrated by ICDH binding. Liposomes induce a conformational change in ICDH, indicating that cardiolipin-rich membrane domains can inhibit ICDH activity. Lipid membranes, including cardiolipin molecules, can act as a platform to regulate ICDH-related metabolic pathways such as the tricarboxylic acid cycle and lipid synthesis
Homo sapiens