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Literature summary extracted from

  • Kenney, J.W.; Genheden, M.; Moon, K.M.; Wang, X.; Foster, L.J.; Proud, C.G.
    Eukaryotic elongation factor 2 kinase regulates thesynthesis of microtubule-related proteins in neurons (2016), J. Neurochem., 136, 276-284.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.20 bicuculline elevation of eEF2K activity with bicuculline, a GABA receptor antagonist Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.20 JAN-384 a JAN-384 highly selective eEF2K inhibitor, comparison to inhibition of other protein kinases Mus musculus
2.7.11.20 JAN-452 slight inhibition Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.20 microtubule
-
 Mus musculus 5874
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.20 Ca2+ required Mus musculus
2.7.11.20 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2] Mus musculus phosphorylation at Thr56 ADP + [elongation factor 2] phosphate
-
 ?
2.7.11.20 ATP + [elongation factor 2] Mus musculus C57/BL6J phosphorylation at Thr56 ADP + [elongation factor 2] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.20 Mus musculus O08796
-
-
2.7.11.20 Mus musculus C57/BL6J O08796
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.20 neuron primary cortical neurons Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2] phosphorylation at Thr56 Mus musculus ADP + [elongation factor 2] phosphate
-
 ?
2.7.11.20 ATP + [elongation factor 2] phosphorylation at Thr56 Mus musculus C57/BL6J ADP + [elongation factor 2] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.20 eEF2K
-
 Mus musculus
2.7.11.20 eukaryotic elongation factor 2 kinase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.20 ATP
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.11.20 0.000005
-
 pH and temperature not specified in the publication Mus musculus JAN-384
2.7.11.20 0.03
-
 pH and temperature not specified in the publication Mus musculus JAN-452

General Information

EC Number General Information Comment Organism
2.7.11.20 malfunction processes related to microtubules are particularly sensitive to eEF2K inhibition Mus musculus
2.7.11.20 physiological function eEF2K likely contributes to neuronal function by regulating the synthesis of microtubule-related proteins. Phosphorylation of elongation factor 2, EF2, results in slower elongation which then result in the increased synthesis of specific proteins. Expression levels of eEF2K targets with unaltered, enhanced, and reduced eEF2K enzyme activity, overview. Synthesis of MAP1B, ARC, and CAMKIIa is sensitive to eEF2K inhibition Mus musculus