EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.98.3 | (5-chloro-1-methyl-1H-pyrazol-4-yl)(3-endo-3-((5-fluoro-1H-indazol-3-yl)amino)-8-azabicyclo[3.2.1]oct-8-yl)methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | (5-chloro-1-methyl-1H-pyrazol-4-yl)(4-((2-methoxyquinolin-4-yl)amino)piperidin-1-yl)methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | (5-chloro-1-methyl-1H-pyrazol-4-yl)(4-((5-fluoro-1H-indazol-3-yl)amino)piperidin-1-yl)methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | (5-chloro-1-methyl-1H-pyrazol-4-yl)(4-(cinnolin-4-ylamino)-piperidin-1-yl)methanone | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((1R,3R,5S)-8-((4,5-dimethylisoxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6,7-difluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-1-methyl-1,8-naphthyridin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoro-1-methylquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-phenylpyridin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((1R,3S,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((2S,4R)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)-6,7-difluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((2S,4R)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-(((2S,4S)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((1,5-dimethyl-1H-1,2,3-triazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((1,5-dimethyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)-amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((4,5-dimethyl-1,2-oxazol-3-yl)carbonyl)piperidin-4-yl)-amino)-6,7-difluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-ethyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)-amino)-6-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-isopropyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)azetidin-3-yl)amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-1-ethylquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-1-methylquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-phenylpyridin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-7,8-difluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-7-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-8-fluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)methylamino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)oxy)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)pyrrolidin-3-yl)amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((3-endo-8-((4,5-Dimethyl-1,2-oxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 4-((3-endo-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-6,7-difluoroquinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 6-fluoro-4-((1-((1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-carbonyl)piperidin-4-yl)amino)quinolin-2(1H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | 8-((3-endo-8-((4,5-dimethyl-1,2-oxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-5-methylpyrido[2,3-b]pyrazin-6(5H)-one | - |
Mycobacterium tuberculosis | |
1.1.98.3 | BTZ043 | - |
Mycobacterium tuberculosis | |
1.1.98.3 | isoniazid | - |
Mycobacterium tuberculosis | |
1.1.98.3 | moxifloxacin | - |
Mycobacterium tuberculosis | |
1.1.98.3 | N-(2-fluoroethyl)-1-((6-methoxy-5-methylpyrimidin-4-yl)methyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide | - |
Mycobacterium tuberculosis | |
1.1.98.3 | PBTZ169 | - |
Mycobacterium tuberculosis | |
1.1.98.3 | rifampicin | - |
Mycobacterium tuberculosis | |
1.1.98.3 | TCA1 | - |
Mycobacterium tuberculosis | |
1.1.98.3 | TMC207 | - |
Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | Mycobacterium tuberculosis | - |
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.98.3 | Mycobacterium tuberculosis | P9WJF1 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.98.3 | trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD | - |
Mycobacterium tuberculosis | trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.98.3 | decaprenylphosphoryl-beta-D-ribose 2'-epimerase | - |
Mycobacterium tuberculosis |
1.1.98.3 | DprE1 | - |
Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.98.3 | FAD | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.98.3 | 0.000005 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000006 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000006 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000007 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((1R,3R,5S)-8-((4,5-dimethylisoxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6,7-difluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000007 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-7-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000008 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | |
1.1.98.3 | 0.000009 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-7,8-difluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000009 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((3-endo-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-6,7-difluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000011 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((1,5-dimethyl-1H-1,2,3-triazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000011 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-8-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000012 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoro-1-methylquinolin-2(1H)-one | |
1.1.98.3 | 0.000017 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((3-endo-8-((4,5-Dimethyl-1,2-oxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | |
1.1.98.3 | 0.000018 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((4,5-dimethyl-1,2-oxazol-3-yl)carbonyl)piperidin-4-yl)-amino)-6,7-difluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.00002 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | |
1.1.98.3 | 0.000021 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((2S,4R)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)-6,7-difluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000021 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 6-fluoro-4-((1-((1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-carbonyl)piperidin-4-yl)amino)quinolin-2(1H)-one | |
1.1.98.3 | 0.000026 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-1-methyl-1,8-naphthyridin-2(1H)-one | |
1.1.98.3 | 0.000026 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((2S,4R)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)quinolin-2(1H)-one | |
1.1.98.3 | 0.00003 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000038 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((4,5-dimethylisoxazol-3-yl)carbonyl)piperidin-4-yl)amino)-6,7-difluoro-1-methylquinolin-2(1H)-one | |
1.1.98.3 | 0.000045 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-ethyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)-amino)-6-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.000053 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((1R,3R,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-phenylpyridin-2(1H)-one | |
1.1.98.3 | 0.00012 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | (5-chloro-1-methyl-1H-pyrazol-4-yl)(3-endo-3-((5-fluoro-1H-indazol-3-yl)amino)-8-azabicyclo[3.2.1]oct-8-yl)methanone | |
1.1.98.3 | 0.00013 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | (5-chloro-1-methyl-1H-pyrazol-4-yl)(4-((5-fluoro-1H-indazol-3-yl)amino)piperidin-1-yl)methanone | |
1.1.98.3 | 0.00014 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-1-methylquinolin-2(1H)-one | |
1.1.98.3 | 0.000183 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 8-((3-endo-8-((4,5-dimethyl-1,2-oxazol-3-yl)carbonyl)-8-azabicyclo[3.2.1]oct-3-yl)amino)-5-methylpyrido[2,3-b]pyrazin-6(5H)-one | |
1.1.98.3 | 0.00021 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((1,5-dimethyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)-amino)quinolin-2(1H)-one | |
1.1.98.3 | 0.0018 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)azetidin-3-yl)amino)quinolin-2(1H)-one | |
1.1.98.3 | 0.0022 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-quinolin-2(1H)-one | |
1.1.98.3 | 0.003 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-6-phenylpyridin-2(1H)-one | |
1.1.98.3 | 0.0047 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)pyrrolidin-3-yl)amino)quinolin-2(1H)-one | |
1.1.98.3 | 0.007 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-isopropyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)quinolin-2(1H)-one | |
1.1.98.3 | 0.008 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)oxy)quinolin-2(1H)-one | |
1.1.98.3 | 0.01 | - |
IC50 above 0.01 mM, at pH 8.5 and 25°C | Mycobacterium tuberculosis | (5-chloro-1-methyl-1H-pyrazol-4-yl)(4-(cinnolin-4-ylamino)-piperidin-1-yl)methanone | |
1.1.98.3 | 0.01 | - |
IC50 above 0.01 mM, at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((2S,4S)-1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-2-methylpiperidin-4-yl)amino)quinolin-2(1H)-one | |
1.1.98.3 | 0.018 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)methylamino)quinolin-2(1H)-one | |
1.1.98.3 | 0.043 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-(((1R,3S,5S)-8-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-fluoroquinolin-2(1H)-one | |
1.1.98.3 | 0.078 | - |
at pH 8.5 and 25°C | Mycobacterium tuberculosis | (5-chloro-1-methyl-1H-pyrazol-4-yl)(4-((2-methoxyquinolin-4-yl)amino)piperidin-1-yl)methanone | |
1.1.98.3 | 0.1 | - |
IC50 above 0.1 mM, at pH 8.5 and 25°C | Mycobacterium tuberculosis | 4-((1-((5-chloro-1-methyl-1H-pyrazol-4-yl)carbonyl)piperidin-4-yl)amino)-1-ethylquinolin-2(1H)-one |