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Literature summary extracted from

  • Luu, W.; Hart-Smith, G.; Sharpe, L.J.; Brown, A.J.
    The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally (2015), J. Lipid Res., 56, 888-897.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.21 expressed in CHO-EV and CHO-DHCR24-V5 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.21 cholesterol + NADP+ Homo sapiens
-
 cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.21 cholesterol + NADP+
-
 Homo sapiens cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.21 Dhcr7
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.21 NADP+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.3.1.21 metabolism the enzyme is important for both cholesterol and vitamin D synthesis Homo sapiens