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Literature summary extracted from

  • Liao, Y.; Chu, H.P.; Hu, Z.; Merkin, J.J.; Chen, J.; Liu, Z.; Degenhardt, K.; White, E.; Ryazanov, A.G.
    Paradoxical roles of elongation factor-2 kinase in stem cell survival (2016), J. Biol. Chem., 291, 19545-19557.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.20 Calmodulin required Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.20 Ca2+ required Mus musculus
2.7.11.20 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2] Mus musculus
-
 ADP + [elongation factor 2] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.20 Mus musculus O08796
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.20 hematopoietic stem cell
-
 Mus musculus
-
2.7.11.20 ovary
-
 Mus musculus
-
2.7.11.20 skeletal muscle
-
 Mus musculus
-
2.7.11.20 small intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2]
-
 Mus musculus ADP + [elongation factor 2] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.20 eEF2K
-
 Mus musculus
2.7.11.20 elongation factor-2 kinase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.20 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.11.20 malfunction knockout of eEF2K protects mice from a lethal dose of whole-body ionizing radiation at 8 Gy by reducing apoptosis levels in both bone marrow and gastrointestinal tracts. eEF2K deficiency results in more severe damage to the gastrointestinal tract at 20 Gy with the increased mitotic cell death in small intestinal stem cells. Elevation of Akt/ERK activity as well as the reduction of p21 expression occur in Eef2k-/- cells Eef2k-/- mice display opposite sensitivities at low dose and high dose of ionizing radiation according to tissue and cell types, overview. Consistent with the role of eEF2K in apoptosis, cleaved caspase-3-positive and TUNEL-positive cells are reduced in Eef2k-deficient mice Mus musculus
2.7.11.20 physiological function elongation factor-2 kinase (eEF2K), a protein kinase that suppresses protein synthesis during elongation phase, is a positive regulator of apoptosis both in vivo and in vitro. eEF2K is required for G2/M arrest induced by radiation to prevent mitotic catastrophe in a p53-independent manner in epithelial cells. eEF2K also provides a protective strategy to maintain genomic integrity by arresting cell cycle in response to stress. Protective versus pro-apoptotic roles of eEF2K depend on the type of cells: eEF2K is protective in highly proliferative cells, such as small intestinal stem cells and cancer cells, which are more susceptible to mitotic catastrophe. The dynamics of eEF2K activity in DNA damage response is distinct in different cell types and are related to cell proliferating status. eEF2K suppresses intestinal mitotic cell death in response to gamma-irradiation Mus musculus