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Literature summary extracted from

  • Budak, H.; Ceylan, H.; Kocpinar, E.F.; Gonul, N.; Erdogan, O.
    Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liver (2014), J. Biochem. Mol. Toxicol., 28, 217-223.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.44 Fe3+
-
 Rattus norvegicus
1.1.1.49 Fe3+ enzyme activities are significantly decreased in the presence of 30 and 300 ppm Fe3+ Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.49 additional information 0.87 and 3 ppm Fe3+ concentrations have no significant effect on enzyme activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Rattus norvegicus
-
 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
1.1.1.49 D-glucose 6-phosphate + NADP+ Rattus norvegicus
-
 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Rattus norvegicus
-
-
-
1.1.1.49 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.44 liver
-
 Rattus norvegicus
-
1.1.1.49 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
 Rattus norvegicus D-ribulose 5-phosphate + CO2 + NADPH + H+
-
 ?
1.1.1.49 D-glucose 6-phosphate + NADP+
-
 Rattus norvegicus 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase
-
 Rattus norvegicus
1.1.1.44 6PGD
-
 Rattus norvegicus
1.1.1.49 G6PD
-
 Rattus norvegicus
1.1.1.49 glucose-6-phosphate 1-dehydrogenase
-
 Rattus norvegicus
1.1.1.49 glucose-6-phosphate dehydrogenase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.44 NADP+ dependent on Rattus norvegicus
1.1.1.49 NADP+
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.1.1.44 Rattus norvegicus the nontoxic (0.87 ppm) level of Fe3+ treatment leads to transcriptional activation for the enzyme up