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Literature summary extracted from

  • Meredith, T.C.; Swoboda, J.G.; Walker, S.
    Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus (2008), J. Bacteriol., 190, 3046-3056.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.46 Staphylococcus aureus Q2G1C2
-
-
2.7.8.46 Staphylococcus aureus NCTC 8325 Q2G1C2
-
-
2.7.8.47 Staphylococcus aureus Q2G1C2
-
-
2.7.8.47 Staphylococcus aureus NCTC 8325 Q2G1C2
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.46 CDP-ribitol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus CMP + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.7.8.46 CDP-ribitol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus NCTC 8325 CMP + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.7.8.46 additional information TarK is a bifunctional enzyme that catalyzes both ribitol phosphate priming and polymerization, reactions of EC 2.7.18.46 and 2.7.8.47. TarK directs the synthesis of a polyribitol-containing teichoic acid K-WTA Staphylococcus aureus ?
-
 ?
2.7.8.46 additional information TarK is a bifunctional enzyme that catalyzes both ribitol phosphate priming and polymerization, reactions of EC 2.7.18.46 and 2.7.8.47. TarK directs the synthesis of a polyribitol-containing teichoic acid K-WTA Staphylococcus aureus NCTC 8325 ?
-
 ?
2.7.8.47 additional information TarK is a bifunctional enzyme that catalyzes both ribitol phosphate priming and polymerization, reactions of EC 2.7.18.46 and 2.7.8.47. TarK directs the synthesis of a polyribitol-containing teichoic acid K-WTA Staphylococcus aureus ?
-
 ?
2.7.8.47 additional information TarK is a bifunctional enzyme that catalyzes both ribitol phosphate priming and polymerization, reactions of EC 2.7.18.46 and 2.7.8.47. TarK directs the synthesis of a polyribitol-containing teichoic acid K-WTA Staphylococcus aureus NCTC 8325 ?
-
 ?
2.7.8.47 n CDP-ribitol + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus n CMP + 4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?
2.7.8.47 n CDP-ribitol + 4-O-[1-D-ribitylphospho-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 Staphylococcus aureus NCTC 8325 n CMP + 4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.46 tarK
-
 Staphylococcus aureus
2.7.8.47 tarK
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.7.8.46 physiological function TarK is a bifunctional enzyme that catalyzes both ribitol phosphate priming and polymerization, reactions of EC 2.7.18.46 and 2.7.8.47. TarK can replace polymerase TarL provided that it is sufficiently expressed. TarK directs the synthesis of a polyribitol-containing teichoic acid K-WTA. The biosynthesis of K-WTA is repressed by the accessory gene regulator (agr) system Staphylococcus aureus
2.7.8.47 physiological function TarK is a bifunctional enzyme that catalyzes both ribitol phosphate priming and polymerization, reactions of EC 2.7.18.46 and 2.7.8.47. TarK can replace polymerase TarL provided that it is sufficiently expressed. TarK directs the synthesis of a polyribitol-containing teichoic acid K-WTA. The biosynthesis of K-WTA is repressed by the accessory gene regulator (agr) system Staphylococcus aureus