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Literature summary extracted from

  • Mizuno, H.; Yazawa, T.; Kasuga, S.; Sawada, Y.; Kanamori, H.; Ogo, Y.; Hirai, M.Y.; Matsumoto, T.; Kawahigashi, H.
    Expression of flavone synthase II and flavonoid 3'-hydroxylase is associated with color variation in tan-colored injured leaves of Sorghum (2016), Front. Plant Sci., 7, 1718.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.234 gene P or Sb06g029550, genetic structure, quantitative RT-PCR enzyme expression analysis Sorghum bicolor

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.234 additional information expression of both flavone synthase II (FNSII) and flavonoid 3'-hydroxylase (F3'H) leads to the synthesis of apigenin and luteolin in cultivar #7, and expression of both flavanone 4-reductase and F3'H leads to the synthesis of 3-deoxyanthocyanidins in cultivar Nakei-MS3B Sorghum bicolor

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.234 (2S)-flavan-4-ol + NADP+ Sorghum bicolor
-
 (2S)-flavanone + NADPH + H+
-
 ?
1.1.1.234 eriodictyol + NADP+ Sorghum bicolor
-
 luteoforol + NADPH + H+
-
 ?
1.1.1.234 naringenin + NADPH + H+ Sorghum bicolor
-
 apiforol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.234 Sorghum bicolor C5YGL7 cultivars #7, M36001, and Nakei
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.234 leaf
-
 Sorghum bicolor
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.234 (2S)-flavan-4-ol + NADP+
-
 Sorghum bicolor (2S)-flavanone + NADPH + H+
-
 ?
1.1.1.234 eriodictyol + NADP+
-
 Sorghum bicolor luteoforol + NADPH + H+
-
 ?
1.1.1.234 additional information enzyme FNR converts flavanones to flavan-4-ols Sorghum bicolor ?
-
 ?
1.1.1.234 naringenin + NADPH + H+
-
 Sorghum bicolor apiforol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.234 3-deoxyanthocyanidin synthase
-
 Sorghum bicolor
1.1.1.234 FNR
-
 Sorghum bicolor
1.1.1.234 Sb06g029550
-
 Sorghum bicolor

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.234 NADP+
-
 Sorghum bicolor

Expression

EC Number Organism Comment Expression
1.1.1.234 Sorghum bicolor the enzyme is highly induced by cutting stress up

General Information

EC Number General Information Comment Organism
1.1.1.234 malfunction Sorghums with a tan injury response have non-functional FNR alleles (p). The FNR gene of cultivar M36001 has an insertion in the coding region. Sorghums with a tan injury response have lower levels of flavan-4-ols (precursors of apigeninidin and luteolinidin-apiforol and luteoforol, respectively) than do sorghums with a purple or red injury response and are unable to synthesize 3-deoxyanthocyanidins Sorghum bicolor
1.1.1.234 physiological function the enzyme is responsible for the synthesis of 3-deoxyanthocyanidins. The variation of purple-red-orange is explained by the balance of two 3-deoxyanthocyanidins, uteolinidin and apigeninidin. The balance is controlled by the expression level of flavonoid 3'-hydroxylase (F3'H), which encodes a protein that hydroxylates the 3' position of the B-ring of naringenin to produce a precursor of luteolinidin Sorghum bicolor