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Literature summary extracted from

  • Tian, L.; Wang, Y.; Yu, J.; Xiong, D.; Zhao, H.; Tian, C.
    The mitogen-activated protein kinase kinase VdPbs2 of Verticillium dahliae regulates microsclerotia formation, stress response, and plant infection (2016), Front. Microbiol., 7, 1532.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.12.2 additional information targeted disruption of gene VdPbs2 and mutant complementation with the VdPbs2-GFP fusion construct containing the native promoter and coding region of VdPbs2 Verticillium dahliae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.12.2 cytoplasm
-
 Verticillium dahliae 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.12.2 Mg2+ required Verticillium dahliae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.12.2 ATP + a protein Verticillium dahliae
-
 ADP + a phosphoprotein
-
 ?
2.7.12.2 ATP + a protein Verticillium dahliae XS11
-
 ADP + a phosphoprotein
-
 ?
2.7.12.2 ATP + VdHog1 Verticillium dahliae VdHog1 is a mitogen-activated protein kinase, MAPK ADP + phosphorylated VdHog1
-
 ?
2.7.12.2 ATP + VdHog1 Verticillium dahliae XS11 VdHog1 is a mitogen-activated protein kinase, MAPK ADP + phosphorylated VdHog1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.12.2 Verticillium dahliae
-
 isolated from a smoke tree, Cotinuscoggygria in Fragrant Hills Park,Beijing
-
2.7.12.2 Verticillium dahliae XS11
-
 isolated from a smoke tree, Cotinuscoggygria in Fragrant Hills Park,Beijing
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.12.2 conidium
-
 Verticillium dahliae
-
2.7.12.2 microsclerotium
-
 Verticillium dahliae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.12.2 ATP + a protein
-
 Verticillium dahliae ADP + a phosphoprotein
-
 ?
2.7.12.2 ATP + a protein
-
 Verticillium dahliae XS11 ADP + a phosphoprotein
-
 ?
2.7.12.2 ATP + VdHog1 VdHog1 is a mitogen-activated protein kinase, MAPK Verticillium dahliae ADP + phosphorylated VdHog1
-
 ?
2.7.12.2 ATP + VdHog1 VdHog1 is a mitogen-activated protein kinase, MAPK Verticillium dahliae XS11 ADP + phosphorylated VdHog1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.12.2 MAPKK
-
 Verticillium dahliae
2.7.12.2 MEK
-
 Verticillium dahliae
2.7.12.2 mitogen-activated protein kinase kinase
-
 Verticillium dahliae
2.7.12.2 VdPbs2
-
 Verticillium dahliae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.12.2 ATP
-
 Verticillium dahliae

General Information

EC Number General Information Comment Organism
2.7.12.2 malfunction VdPbs2 deletion strains exhibit delayed melanin synthesis and reduced formation of microsclerotia, similar to a VdHog1 deletion mutant. When exposed to stresses, VdPbs2 mutants are more sensitive than the wild-type to osmotic agents and peroxide, but more resistant to inhibitors of cell wall synthesis and some fungicides. VdPbs2 deletion mutants exhibit reduced virulence on smoke tree and tobacco seedlings. Transcript analysis revealed´s that three genes(VDAG_08724, VDAG_03661,and VDAG_06340) are consistently downregulated in the 1VdPbs2 mutant compared to that of the wild-type after treated with 1 mM H2O2 for 30 min. Phentypes, overview Verticillium dahliae
2.7.12.2 physiological function mitogen-activated protein kinase kinase VdPbs2 is a key regulator of microsclerotia formation, oxidative stress and fungicide response and plant virulence in Verticillium dahliae via regulating the activity of VdHog1, a mitogen-activated protein kinase, MAPK. VdPbs2 and VdHog1 function in a cascade that regulates microsclerotia formation and virulence, but not all VdHog1 dependent functions are VdPbs2 regulated. VdPbs2 is essential for the oxidative stress response and is required for plant infection, VdPbs2 may be involved in the penetration process during plant infection Verticillium dahliae