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Literature summary extracted from

  • Benjdia, A.; Subramanian, S-; Leprince, J.; Vaudry, H.; Johnson, M.K.; Berteau, O.
    Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes (2010), FEBS J., 277, 1906-1920.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.98.7 expressed in Escherichia coli BL21(DE3) Clostridium perfringens
1.8.98.7 expressed in Escherichia coli BL21(DE3) Clostridium perfringens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.98.7 [4Fe-4S]2+ cluster three [4Fe-4S]2+ clusters per enzyme molecule Clostridium perfringens
1.8.98.7 [4Fe-4S]2+ cluster three [4Fe-4S]2+ clusters per enzyme molecule Clostridium perfringens

Organism

EC Number Organism UniProt Comment Textmining
1.1.98.7 Clostridium perfringens Q8XMQ3
-
-
1.1.98.7 Clostridium perfringens type A Q8XMQ3
-
-
1.8.98.7 Clostridium perfringens Q8XMQ3
-
-
1.8.98.7 Clostridium perfringens type A Q8XMQ3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.98.7
-
 Clostridium perfringens
1.8.98.7
-
 Clostridium perfringens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.98.7 Ac-AVPSSIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite Clostridium perfringens Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O
-
 ?
1.1.98.7 Ac-AVPSSIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite Clostridium perfringens type A Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O
-
 ?
1.1.98.7 additional information the enzme also perfoms the reaction of the Cys-type anaerobic sulfatase-maturating enzyme, converting a cysteine residue of sulfatase into a 3-oxo-L-alanine residue. The post-translational modification of sulfatases, i.e. the creation of a 3-oxo-L-alanine (i.e. Calpha-formylglycine) residue from a cysteine or serine is vital for the proper function of sulfatases Clostridium perfringens ?
-
 ?
1.1.98.7 additional information the enzme also perfoms the reaction of the Cys-type anaerobic sulfatase-maturating enzyme, converting a cysteine residue of sulfatase into a 3-oxo-L-alanine residue. The post-translational modification of sulfatases, i.e. the creation of a 3-oxo-L-alanine (i.e. Calpha-formylglycine) residue from a cysteine or serine is vital for the proper function of sulfatases Clostridium perfringens type A ?
-
 ?
1.8.98.7 Ac-AVPSCIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite Clostridium perfringens Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen sulfide
-
 ?
1.8.98.7 Ac-AVPSCIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite Clostridium perfringens type A Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + hydrogen sulfide
-
 ?
1.8.98.7 additional information the enzme also perfoms the reaction of the Ser-type anaerobic sulfatase-maturating enzyme, converting a serine residue of sulfatase into a 3-oxo-L-alanine residue. The post-translational modification of sulfatases, i.e. the creation of a 3-oxo-L-alanine (i.e. Calpha-formylglycine) residue from a cysteine or serine is vital for the proper function of sulfatases Clostridium perfringens ?
-
 ?
1.8.98.7 additional information the enzme also perfoms the reaction of the Ser-type anaerobic sulfatase-maturating enzyme, converting a serine residue of sulfatase into a 3-oxo-L-alanine residue. The post-translational modification of sulfatases, i.e. the creation of a 3-oxo-L-alanine (i.e. Calpha-formylglycine) residue from a cysteine or serine is vital for the proper function of sulfatases Clostridium perfringens type A ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.98.7 anaerobic sulfatase-maturating enzyme
-
 Clostridium perfringens
1.1.98.7 nSMEcpe
-
 Clostridium perfringens
1.8.98.7 anaerobic sulfatase-maturating enzyme
-
 Clostridium perfringens
1.8.98.7 nSMEcpe
-
 Clostridium perfringens

General Information

EC Number General Information Comment Organism
1.1.98.7 metabolism involved in the pathway of sulfatase oxidation Clostridium perfringens
1.8.98.7 metabolism involved in the pathway of sulfatase oxidation Clostridium perfringens