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Literature summary extracted from

  • Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Jenkins, J.L.; Heimiller, C.; Maines, M.D.
    Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation (2016), FASEB J., 30, 2926-2944.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.24 additional information the enzyme is directly activated by insulin receptor kinase Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.24 expressed in Escherichia coli BL-21 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 biliverdin + NADH + H+ Homo sapiens
-
 bilirubin + NAD+
-
 r
1.3.1.24 biliverdin + NADPH + H+ Homo sapiens
-
 bilirubin + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens P53004
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.3.1.24 phosphoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.24 Ni-NTA agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 biliverdin + NADH + H+
-
 Homo sapiens bilirubin + NAD+
-
 r
1.3.1.24 biliverdin + NADPH + H+
-
 Homo sapiens bilirubin + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 biliverdin reductase A
-
 Homo sapiens
1.3.1.24 BVR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.3.1.24 metabolism the enzyme is a coactivator of Akt1 and a key mediator of the Akt1/glycogen synthase kinase 3 pathway Homo sapiens