Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Brooks, K.; Burns, G.; Spencer, T.E.
    Biological roles of hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), HSD11B2, and glucocorticoid receptor (NR3C1) in sheep conceptus elongation (2015), Biol. Reprod., 93, 38.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 morpholino antisense oligonucleotide about 50% inhibition at 0.002 mM; about 50% inhibition at 0.002 mM Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisol + NADP+ Ovis aries
-
 cortisone + NADPH + H+
-
 r
1.1.1.146 cortisone + NADPH + H+ Ovis aries
-
 cortisol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Ovis aries P50168
-
-
1.1.1.146 Ovis aries P51975
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 conceptus trophectoderm
-
 Ovis aries
-
1.1.1.146 endometrial luminal epithelium
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NADP+
-
 Ovis aries cortisone + NADPH + H+
-
 r
1.1.1.146 cortisone + NADPH + H+
-
 Ovis aries cortisol + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 HSD11B1 isoform Ovis aries
1.1.1.146 Hsd11B2 isoform Ovis aries
1.1.1.146 hydroxysteroid (11-beta) dehydrogenase
-
 Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Ovis aries
1.1.1.146 NADPH
-
 Ovis aries