Literature summary extracted from

Liu, Y.; Jia, Z.; Sun, Y.; Zhou, L.; Downton, M.; Chen, R.; Zhang, A.; Yang, T.
Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in the rat kidney (2014), Am. J. Physiol. Renal Physiol., 307, F388-F395.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.141	(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+	Rattus norvegicus	-	(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.141	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.141	kidney	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.141	(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+	-	Rattus norvegicus	(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.141	15-PGDH	-	Rattus norvegicus
1.1.1.141	NAD+-dependent 15-hydroxyprostaglandin dehydrogenase	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.141	NAD+	-	Rattus norvegicus

General Information

EC Number	General Information	Comment	Organism
1.1.1.141	physiological function	the enzyme regulates postnatal kidney development through interaction with cyclooxygenase 2	Rattus norvegicus

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Release 2023.1 (January 2023)