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Literature summary extracted from

  • Chang, C.C.; Few, L.L.; Konrad, M.; See Too, W.C.
    Phosphorylation of human choline kinase beta by protein kinase A: its impact on activity and inhibition (2016), PLoS ONE, 11, e0154702.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.32 S39D/S40D the choline kinase beta phosphorylation mimic behaves kinetically like the wild type enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.32 hemicholinium-3
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.32 0.42
-
 choline phosphorylated choline kinase beta, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 0.46
-
 choline mutant choline kinase beta S39D/S40D, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 0.58
-
 ATP mutant choline kinase beta S39D/S40D, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 0.65
-
 ATP phosphorylated choline kinase beta, at pH 7.5 and 30°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.32 45000
-
 x * 45000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.32 ATP + choline Homo sapiens
-
 ADP + phosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Homo sapiens Q9Y259
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.32 phosphoprotein choline kinase beta is phosphorylated by protein kinase A Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
-
 Homo sapiens ADP + phosphocholine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.32 ? x * 45000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 choline kinase beta
-
 Homo sapiens
2.7.1.32 CKbeta
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.32 45.31
-
 choline mutant choline kinase beta S39D/S40D, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 48.25
-
 choline phosphorylated choline kinase beta, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 50.48
-
 ATP mutant choline kinase beta S39D/S40D, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 54.39
-
 ATP phosphorylated choline kinase beta, at pH 7.5 and 30°C Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.32 physiological function choline kinase beta, in concert with choline kinase alpha, and depending on its phosphorylation status, plays a critical role in carcinogenesis Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.1.32 83.69
-
 ATP phosphorylated choline kinase beta, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 86.24
-
 ATP mutant choline kinase beta S39D/S40D, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 98.5
-
 choline mutant choline kinase beta S39D/S40D, at pH 7.5 and 30°C Homo sapiens
2.7.1.32 114.9
-
 choline phosphorylated choline kinase beta, at pH 7.5 and 30°C Homo sapiens