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Literature summary extracted from

  • Belyy, A.; Tabakova, I.; Lang, A.E.; Jank, T.; Belyi, Y.; Aktories, K.
    Roles of Asp179 and Glu270 in ADP-ribosylation of actin by Clostridium perfringens iota toxin (2015), PLoS ONE, 10, e0145708.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.31 NAD+ + [actin]-L-arginine177 Clostridium perfringens
-
 nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.31 Clostridium perfringens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.31 additional information actin with substitution of Asp179 (but not Arg177 and less Glu270) is sensitive towards the toxic action of the enzyme Clostridium perfringens additional information
-
 ?
2.4.2.31 NAD+ + [actin]-L-arginine177
-
 Clostridium perfringens nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.31 binary toxin component Ia
-
 Clostridium perfringens
2.4.2.31 iota toxin
-
 Clostridium perfringens