BRENDA - Enzyme Database

CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway

Liu, Y.; Wang, W.; Shui, G.; Huang, X.; PLoS Genet. 10, e1004172 (2014)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Drosophila melanogaster
-
diphosphate + CDP-diacylglycerol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.41
Drosophila melanogaster
-
-
-
2.7.7.41
Drosophila melanogaster
P56079
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
brain
-
Drosophila melanogaster
-
2.7.7.41
eye
high enzyme content
Drosophila melanogaster
-
2.7.7.41
fat body
-
Drosophila melanogaster
-
2.7.7.41
hindgut
-
Drosophila melanogaster
-
2.7.7.41
insect tracheal system
-
Drosophila melanogaster
-
2.7.7.41
malpighian tubule
-
Drosophila melanogaster
-
2.7.7.41
additional information
CdsA is widely expressed in different larval tissues. Broad expression of CdsA
Drosophila melanogaster
-
2.7.7.41
muscle
-
Drosophila melanogaster
-
2.7.7.41
proventriculus
-
Drosophila melanogaster
-
2.7.7.41
salivary gland
-
Drosophila melanogaster
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
739396
Drosophila melanogaster
diphosphate + CDP-diacylglycerol
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Drosophila melanogaster
-
diphosphate + CDP-diacylglycerol
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
brain
-
Drosophila melanogaster
-
2.7.7.41
eye
high enzyme content
Drosophila melanogaster
-
2.7.7.41
fat body
-
Drosophila melanogaster
-
2.7.7.41
hindgut
-
Drosophila melanogaster
-
2.7.7.41
insect tracheal system
-
Drosophila melanogaster
-
2.7.7.41
malpighian tubule
-
Drosophila melanogaster
-
2.7.7.41
additional information
CdsA is widely expressed in different larval tissues. Broad expression of CdsA
Drosophila melanogaster
-
2.7.7.41
muscle
-
Drosophila melanogaster
-
2.7.7.41
proventriculus
-
Drosophila melanogaster
-
2.7.7.41
salivary gland
-
Drosophila melanogaster
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
739396
Drosophila melanogaster
diphosphate + CDP-diacylglycerol
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
2.7.7.41
malfunction
loss of CdsA function causes significant accumulation of neutral lipids in many tissues along with reduced cell/organ size. These phenotypes can be traced back to reduced phosphatidylinositol levels and, subsequently, low insulin pathway activity. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants. A diacylglycerol-to-phosphatidylethanolamine route mediated by the choline/ethanolamine phosphotransferase Bbc may contribute to the growth of fat cells in silenced CdsA RNAi. CdsA RNAi affects phosphatidylinositol metabolism and insulin pathway activity, strong salivary gland fat storage phenotype of CdsA RNAi. CdsA mutations affect salivary gland fat storage and cell size. But loss of function of CdsA does not affect fat cell lipid storage and growth
Drosophila melanogaster
2.7.7.41
physiological function
loss of CdsA function causes significant accumulation of neutral lipids in many tissues along with reduced cell/organ size. These phenotypes can be traced back to reduced phosphatidylinositol levels and, subsequently, low insulin pathway activity. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants. CdsA regulates salivary gland fat storage and cell size; the enzyme diverts phosphatidic acid from triacylglycerol synthesis to phosphatidylinositol synthesis and coordinates cell growth and fat storage. Enzyme CdsA coordinates cell/tissue growth and lipid storage through the insulin pathway. The enzyme is important for the phototransduction pathway. CdsA regulates salivary gland fat storage and cell size
Drosophila melanogaster
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.7.7.41
malfunction
loss of CdsA function causes significant accumulation of neutral lipids in many tissues along with reduced cell/organ size. These phenotypes can be traced back to reduced phosphatidylinositol levels and, subsequently, low insulin pathway activity. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants. A diacylglycerol-to-phosphatidylethanolamine route mediated by the choline/ethanolamine phosphotransferase Bbc may contribute to the growth of fat cells in silenced CdsA RNAi. CdsA RNAi affects phosphatidylinositol metabolism and insulin pathway activity, strong salivary gland fat storage phenotype of CdsA RNAi. CdsA mutations affect salivary gland fat storage and cell size. But loss of function of CdsA does not affect fat cell lipid storage and growth
Drosophila melanogaster
2.7.7.41
physiological function
the enzyme diverts phosphatidic acid from triacylglycerol synthesis to phosphatidylinositol synthesis and coordinates cell growth and fat storage. Enzyme CdsA coordinates cell/tissue growth and lipid storage through the insulin pathway. The enzyme is important for the phototransduction pathway. CdsA regulates salivary gland fat storage and cell size
Drosophila melanogaster
2.7.7.41
physiological function
loss of CdsA function causes significant accumulation of neutral lipids in many tissues along with reduced cell/organ size. These phenotypes can be traced back to reduced phosphatidylinositol levels and, subsequently, low insulin pathway activity. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants. CdsA regulates salivary gland fat storage and cell size
Drosophila melanogaster