Literature summary extracted from

Morton, N.M.; Beltram, J.; Carter, R.N.; Michailidou, Z.; Gorjanc, G.; McFadden, C.; Barrios-Llerena, M.E.; Rodriguez-Cuenca, S.; Gibbins, M.T.; Aird, R.E.; Moreno-Navarrete, J.M.; Munger, S.C.; Svenson, K.L.; Gastaldello, A.; Ramage, L.; Naredo, G.; Zeyda, M.; Wang, Z.V.; Howie, A.F.; Saari, A.; Sipila, P.
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness (2016), Nat. Med., 22, 771-779.

Application

EC Number	Application	Comment	Organism
2.8.1.1	medicine	enzyme mRNA expression in adipose tissue correlates positively with insulin sensitivity in adipose tissue and negatively with fat mass. Genetic enzyme identification as a beneficial regulator of adipocyte mitochondrial function has therapeutic significance for individuals with type 2 diabetes	Mus musculus

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.8.1.1	mitochondrion	-	Mus musculus	5739	-

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.8.1.1	thiosulfate + cyanide	Mus musculus	-	sulfite + thiocyanate	-	?

EC Number	Organism	UniProt	Comment	Textmining
2.8.1.1	Mus musculus	-	-	-

EC Number	Source Tissue	Comment	Organism	Textmining
2.8.1.1	adipocyte	-	Mus musculus	-

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.8.1.1	thiosulfate + cyanide	-	Mus musculus	sulfite + thiocyanate	-	?

EC Number	Synonyms	Comment	Organism
2.8.1.1	rhodanese	-	Mus musculus
2.8.1.1	TST	-	Mus musculus

EC Number	General Information	Comment	Organism
2.8.1.1	malfunction	enzyme-deficient mice show markedly exacerbated diabetes	Mus musculus
2.8.1.1	physiological function	enzyme overexpression in adipocytes protects mice from diet-induced obesity and insulin-resistant diabetes	Mus musculus