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Literature summary extracted from

  • Noguchi, F.; Tanifuji, G.; Brown, M.; Fujikura, K.; Takishita, K.
    Complex evolution of two types of cardiolipin synthase in the eukaryotic lineage stramenopiles (2016), Mol. Phylogenet. Evol., 101, 133-141.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.B10 CLS_pld, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview Wobblia lunata
2.7.8.B10 CLS_pld, phylogenetic analysis, overview Cafeteria sp.
2.7.8.B10 CLS_pld, phylogenetic analysis, overview Cantina marsupialis
2.7.8.41 CLS_cap, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview Wobblia lunata
2.7.8.41 CLS_cap, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview Cafeteria roenbergensis
2.7.8.41 CLS_cap, DNA and amino acid sequence determination and analysis, phylogenetic analysis, overview Developayella elegans
2.7.8.41 CLS_pld, phylogenetic analysis, overview Cafeteria sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.B10 additional information in mitochondrion-related organelles (degenerated mitochondria) Cantina marsupialis
-
-
2.7.8.41 mitochondrion
-
 Developayella elegans 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol Wobblia lunata
-
 a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol Cafeteria sp.
-
 a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol Cantina marsupialis
-
 a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol Wobblia lunata NIES1015
-
 a cardiolipin + glycerol
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Wobblia lunata
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Cafeteria roenbergensis
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Developayella elegans
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Developayella elegans NIES1388
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Cafeteria roenbergensis NIES1012
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol Wobblia lunata NIES1015
-
 a cardiolipin + CMP
-
 ?
2.7.8.41 a phosphatidylglycerol + a phosphatidylglycerol Cafeteria sp.
-
 a cardiolipin + glycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.B10 Cafeteria sp.
-
 Caron, lab isolate
-
2.7.8.B10 Cantina marsupialis
-
 a free-living anaerobic stramenopile
-
2.7.8.B10 no activity in Cafeteria roenbergensis
-
 strain NIES1012
-
2.7.8.B10 no activity in Developayella elegans
-
 strain NIES1388
-
2.7.8.B10 Wobblia lunata
-
-
-
2.7.8.B10 Wobblia lunata NIES1015
-
-
-
2.7.8.41 Cafeteria roenbergensis
-
-
-
2.7.8.41 Cafeteria roenbergensis NIES1012
-
-
-
2.7.8.41 Cafeteria sp.
-
 Caron, lab isolate
-
2.7.8.41 Developayella elegans
-
-
-
2.7.8.41 Developayella elegans NIES1388
-
-
-
2.7.8.41 Wobblia lunata
-
-
-
2.7.8.41 Wobblia lunata NIES1015
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol
-
 Wobblia lunata a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol
-
 Cafeteria sp. a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol
-
 Cantina marsupialis a cardiolipin + glycerol
-
 ?
2.7.8.B10 a phosphatidylglycerol + a phosphatidylglycerol
-
 Wobblia lunata NIES1015 a cardiolipin + glycerol
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Wobblia lunata a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Cafeteria roenbergensis a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Developayella elegans a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Developayella elegans NIES1388 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Cafeteria roenbergensis NIES1012 a cardiolipin + CMP
-
 ?
2.7.8.41 a CDP-diacylglycerol + a phosphatidylglycerol
-
 Wobblia lunata NIES1015 a cardiolipin + CMP
-
 ?
2.7.8.41 a phosphatidylglycerol + a phosphatidylglycerol
-
 Cafeteria sp. a cardiolipin + glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.B10 cardiolipin synthase
-
 Wobblia lunata
2.7.8.B10 cardiolipin synthase
-
 Cafeteria sp.
2.7.8.B10 cardiolipin synthase
-
 Cantina marsupialis
2.7.8.B10 CL synthase
-
 Wobblia lunata
2.7.8.B10 CL synthase
-
 Cafeteria sp.
2.7.8.B10 CL synthase
-
 Cantina marsupialis
2.7.8.B10 CLS_pld
-
 Wobblia lunata
2.7.8.B10 CLS_pld
-
 Cafeteria sp.
2.7.8.B10 CLS_pld
-
 Cantina marsupialis
2.7.8.41 cardiolipin synthase
-
 Wobblia lunata
2.7.8.41 cardiolipin synthase
-
 Cafeteria roenbergensis
2.7.8.41 cardiolipin synthase
-
 Developayella elegans
2.7.8.41 cardiolipin synthase
-
 Cafeteria sp.
2.7.8.41 CL synthase
-
 Wobblia lunata
2.7.8.41 CL synthase
-
 Cafeteria roenbergensis
2.7.8.41 CL synthase
-
 Developayella elegans
2.7.8.41 CL synthase
-
 Cafeteria sp.
2.7.8.41 CLS_cap
-
 Wobblia lunata
2.7.8.41 CLS_cap
-
 Cafeteria roenbergensis
2.7.8.41 CLS_cap
-
 Developayella elegans
2.7.8.41 CLS_cap
-
 Cafeteria sp.

General Information

EC Number General Information Comment Organism
2.7.8.B10 evolution CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cafeteria sp. Caron contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue Cafeteria sp.
2.7.8.B10 evolution CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cantina marsupialis contains only a CLS_pld enzyme homologue, no CLS_cap, EC 2.7.8.41, homologue Cantina marsupialis
2.7.8.B10 evolution CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Wobblia lunata contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue Wobblia lunata
2.7.8.B10 metabolism cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates Wobblia lunata
2.7.8.B10 metabolism cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates Cafeteria sp.
2.7.8.B10 metabolism cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates Cantina marsupialis
2.7.8.41 evolution CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cafeteria roenbergensis contains only a CLS_cap enzyme homologue, no CLS_pld homologue Cafeteria roenbergensis
2.7.8.41 evolution CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Cafeteria sp. Caron contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue Cafeteria sp.
2.7.8.41 evolution CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Developayella elegans contains only a CLS_cap enzyme homologue, no CLS_pld homologue Developayella elegans
2.7.8.41 evolution CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, and CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, function in bacteria and eukaryotes (mitochondria), respectively. Phylogenetic analysis, overview. Exceptions to the above-mentioned hypothesis regarding CLS phylogenetic distribution, in which CLS_pld and CLS_cap are exclusively found in bacteria and eukaryotes, respectively, are found in actinobacteria and proteobacteria, that contain CLS_cap-like proteins. The eukaryotic supergroups Amoebozoa, Excavata, and Alveolata, a subgroup of the supergroup SAR, have only CLS_pld (without phylogenetic affiliation to any particular bacterial homologues), while the supergroups Opisthokonta (including animals and fungi) and Archaeplastida (including land plants) along with another SAR subgroup stramenopiles possess only CLS_cap (closely related to alpha-proteobacterial homologues). Wobblia lunata contains both, a CLS_cap enzyme homologue, and a CLS_pld homologue Wobblia lunata
2.7.8.41 metabolism cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature ardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma Cafeteria roenbergensis
2.7.8.41 metabolism cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature ardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma Developayella elegans
2.7.8.41 metabolism cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature ardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma Cafeteria sp.
2.7.8.41 metabolism cardiolipin is known to be biosynthesized by either of two phylogenetically distinct enzymes: CL synthase (CLS) with two phospholipase D domains, i.e. CLS_pld, which synthesizes cardiolipin from two molecules of phosphatidylglycerols or CLS with one CDP-alcohol phosphatidyltransferase domain, i.e. CLS_cap, which produces this lipid using a phosphatidylglycerol and a cytidine diphosphate diacylglycerol as substrates. In contrast to the bacterial-type CL, mitochondrial immature cardiolipin synthesized by CLS is further remodeled (reacylated), resulting in mature cardiolipin generally possessing the same fatty acids at sn-1, 2 sites in one molecule. This eukaryotic cardiolipin maturation pathway consists of two steps: in the first step, immature cardiolipin is deacylated into monolysocardiolipin (MLCL) with either cardiolipin-specific phospholipase (CLD) or calcium-independent phospholipase A2 (iPLA2) beta/gamma Wobblia lunata