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Literature summary extracted from

  • Thomaseth, C.; Weber, P.; Hamm, T.; Kashima, K.; Radde, N.
    Modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism (2013), J. Theor. Biol., 337, 174-180.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.27 Golgi apparatus
-
 Homo sapiens 5794
-
2.7.8.27 membrane
-
 Homo sapiens 16020
-
2.7.8.27 trans-Golgi network
-
 Homo sapiens 5802
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 a ceramide + a phosphatidylcholine Homo sapiens
-
 a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Homo sapiens Q86VZ5
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.8.27 a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol positive feedback mechanism from the products to the reactants, in vivo via protein kinase D and the ceramide transfer protein CERT, modeling Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 a ceramide + a phosphatidylcholine
-
 Homo sapiens a sphingomyelin + a 1,2-diacyl-sn-glycerol
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS1
-
 Homo sapiens
2.7.8.27 sphingomyelin synthase 1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.8.27 additional information minimal mathematical model for the sphingomyelin synthase 1 (SMS1) driven conversion of ceramide to sphingomyelin based on chemical reaction kinetics, modeling sphingomyelin synthase 1 driven reaction at the Golgi apparatus can explain data by inclusion of a positive feedback mechanism, this model is not able to qualitatively reproduce experimental measurements on lipid compositions after altering SMS1 activity, overview Homo sapiens
2.7.8.27 physiological function role of SMSs in vesicular trafficking from the Golgi to the plasma membrane Homo sapiens