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Literature summary extracted from

  • Qi, Y.; Kapterian, T.S.; Du, X.; Ma, Q.; Fei, W.; Zhang, Y.; Huang, X.; Dawes, I.W.; Yang, H.
    CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development (2016), J. Lipid Res., 57, 767-780.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.41 additional information transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells Mus musculus
2.7.7.41 additional information transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells Mus musculus
2.7.7.41 additional information transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS1 by 81%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells Homo sapiens
2.7.7.41 additional information transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS2 by 90%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.41 endoplasmic reticulum membrane
-
 Mus musculus 5789
-
2.7.7.41 endoplasmic reticulum membrane
-
 Homo sapiens 5789
-
2.7.7.41 membrane
-
 Mus musculus 16020
-
2.7.7.41 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.41 CTP + phosphatidate Mus musculus
-
 diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate Homo sapiens
-
 diphosphate + CDP-diacylglycerol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.41 Homo sapiens O95674
-
-
2.7.7.41 Homo sapiens Q92903
-
-
2.7.7.41 Mus musculus P98191
-
-
2.7.7.41 Mus musculus Q99L43
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.41 3T3-L1 cell
-
 Mus musculus
-
2.7.7.41 HeLa cell
-
 Homo sapiens
-
2.7.7.41 preadipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.41 CTP + phosphatidate
-
 Mus musculus diphosphate + CDP-diacylglycerol
-
 ?
2.7.7.41 CTP + phosphatidate
-
 Homo sapiens diphosphate + CDP-diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.41 CDP-DAG synthase
-
 Mus musculus
2.7.7.41 CDP-DAG synthase
-
 Homo sapiens
2.7.7.41 CDP-diacylglycerol synthase
-
 Mus musculus
2.7.7.41 CDP-diacylglycerol synthase
-
 Homo sapiens
2.7.7.41 CDS1
-
 Mus musculus
2.7.7.41 CDS1
-
 Homo sapiens
2.7.7.41 CDS2
-
 Mus musculus
2.7.7.41 CDS2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.7.41 malfunction knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocked the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells Mus musculus
2.7.7.41 malfunction knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 in 3T3-L1 preadipocytes has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells Mus musculus
2.7.7.41 malfunction knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells Homo sapiens
2.7.7.41 malfunction knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells Homo sapiens
2.7.7.41 physiological function knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocks the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidic acid species are significantly increased upon knocking down CDS1. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2 Mus musculus
2.7.7.41 physiological function knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidic acid species are increased upon depleting CDS2. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2 Mus musculus
2.7.7.41 physiological function CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage Mus musculus
2.7.7.41 physiological function CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage Homo sapiens