Literature summary extracted from

Rivas, V.; Carmona, R.; Munoz-Chapuli, R.; Mendiola, M.; Nogues, L.; Reglero, C.; Miguel-Martin, M.; Garcia-Escudero, R.; Dorn, G.W.; Hardisson, D.; Mayor, F.; Penela, P.
Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2 (2013), J. Clin. Invest., 123, 4714-4730.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.11.15	ATP + [beta-adrenergic receptor]	Mus musculus	-	ADP + phospho-[beta-adrenergic receptor]	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.11.15	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.11.15	endothelial cell	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.11.15	ATP + [beta-adrenergic receptor]	-	Mus musculus	ADP + phospho-[beta-adrenergic receptor]	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.11.15	G protein-coupled receptor kinase 2	-	Mus musculus
2.7.11.15	GRK2	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
2.7.11.15	malfunction	enzyme ablation leads to marked vascular malformations involving impaired recruitment of mural cells. Enzyme downregulation is a relevant event in the tumoral angiogenic switch	Mus musculus
2.7.11.15	physiological function	G protein-coupled receptor kinase 2 is a key angiogenesis regulator	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)