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Literature summary extracted from

  • Izumikawa, T.; Dejima, K.; Watamoto, Y.; Nomura, K.H.; Kanaki, N.; Rikitake, M.; Tou, M.; Murata, D.; Yanagita, E.; Kano, A.; Mitani, S.; Nomura, K.; Kitagawa, H.
    Chondroitin 4-O-sulfotransferase is indispensable for sulfation of chondroitin and plays an important role in maintaining normal life span and oxidative stress responses in nematodes (2016), J. Biol. Chem., 291, 23294-23304.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.5 expressed in COS-1 cells Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.5 soluble
-
 Caenorhabditis elegans
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.5 3'-phosphoadenylyl sulfate + chondroitin Caenorhabditis elegans
-
 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?
2.8.2.5 3'-phosphoadenylyl sulfate + chondroitin Caenorhabditis elegans N2
-
 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.5 Caenorhabditis elegans Q09272
-
-
2.8.2.5 Caenorhabditis elegans N2 Q09272
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.5 IgG-Sepharose bead chromatography Caenorhabditis elegans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.5 3'-phosphoadenylyl sulfate + chondroitin
-
 Caenorhabditis elegans adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?
2.8.2.5 3'-phosphoadenylyl sulfate + chondroitin
-
 Caenorhabditis elegans N2 adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.5 C41C4.1
-
 Caenorhabditis elegans
2.8.2.5 Chn 4-O-sulfotransferase
-
 Caenorhabditis elegans
2.8.2.5 chondroitin 4-O-sulfotransferase
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.8.2.5 malfunction enzyme deletion mutants exhibit reduced survival rates after synchronization with sodium hypochlorite Caenorhabditis elegans
2.8.2.5 physiological function the enzyme plays an important role in protecting nematodes from oxidative stress Caenorhabditis elegans