Literature summary extracted from
Mejias, M.P.; Cabrera, G.; Fernandez-Brando, R.J.; Baschkier, A.; Ghersi, G.; Abrey-Recalde, M.J.; Miliwebsky, E.; Meiss, R.; Goldbaum, F.; Zylberman, V.; Rivas, M.; Palermo, M.S.
Protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera (2014), Infect. Immun., 82, 1491-1499.
Application
EC Number |
Application |
Comment |
Organism |
---|
2.5.1.78 |
additional information |
protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera. The enzyme can be useful in vaccine development against enterohemorrhagic Shiga toxin (Stx)-producing Escherichia coli (EHEC), which causes a prodromal hemorrhagic enteritis, remaining the most common etiology of the typical or epidemic form of hemolytic-uremic syndrome. The EHEC challenge contributes to sustain a specific and protective immune response against Stx2 |
Brucella sp. |
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
2.5.1.78 |
recombinant expression of a His-tagged fusion protein BLS-Stx2B formed by the enzyme and the Shiga toxin B subunit |
Brucella sp. |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.5.1.78 |
Brucella sp. |
- |
- |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
2.5.1.78 |
recombinant His-tagged fusion protein BLS-Stx2B by nickel affinity chromatography |
Brucella sp. |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.5.1.78 |
BLS |
- |
Brucella sp. |
2.5.1.78 |
lumazine synthase |
- |
Brucella sp. |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.5.1.78 |
physiological function |
protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera.Maternal immunization with BLSStx2B protein antigen as a possible approach for transferring anti-Stx2 protection to the offspring |
Brucella sp. |