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Literature summary extracted from

  • Muller, U.; Buckel, W.
    Activation of (R)-2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans (1995), Eur. J. Biochem., 230, 698-704.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.167 activator protein HgdC the enzyme is activated by ATP, MgCl2, and Ti(III)citrate by an activator protein (HgdC) that is present in the organism at very low concentrations. It is suggested that during the activation step, the electron of this cycle is fed into the enzyme by Ti(III)citrate and energized by hydrolysis of ATP. Both functions are apparently catalysed by the activator. The enzyme remains in this activated state for several turnovers Acidaminococcus fermentans

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.167 Acidaminococcus fermentans
-
-
-
4.2.1.167 Acidaminococcus fermentans ATCC 25085
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.167 (E)-glutaconyl-CoA + H2O
-
 Acidaminococcus fermentans (R)-2-hydroxyglutaryl-CoA
-
 r
4.2.1.167 (E)-glutaconyl-CoA + H2O
-
 Acidaminococcus fermentans ATCC 25085 (R)-2-hydroxyglutaryl-CoA
-
 r
4.2.1.167 (R)-2-hydroxyglutaryl-CoA
-
 Acidaminococcus fermentans (E)-glutaconyl-CoA + H2O
-
 r
4.2.1.167 (R)-2-hydroxyglutaryl-CoA
-
 Acidaminococcus fermentans ATCC 25085 (E)-glutaconyl-CoA + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.167 hgdAB
-
 Acidaminococcus fermentans