EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.1 | KCl | - |
Littorina littorea | |
2.7.1.1 | NaCl | - |
Littorina littorea | |
2.7.1.1 | NH4Cl | - |
Littorina littorea | |
2.7.1.1 | Urea | - |
Littorina littorea |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.1 | 0.059 | - |
D-glucose | enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | |
2.7.1.1 | 0.091 | - |
D-glucose | enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | |
2.7.1.1 | 0.14 | - |
ATP | enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | |
2.7.1.1 | 0.15 | - |
D-glucose | enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | |
2.7.1.1 | 0.15 | - |
D-glucose | enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | |
2.7.1.1 | 0.16 | - |
ATP | enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | |
2.7.1.1 | 0.24 | - |
ATP | enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | |
2.7.1.1 | 0.55 | - |
ATP | enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.1 | Littorina littorea | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.1 | foot muscle | during anoxia, an increase in Km for ATP and a decrease in Vmax for anoxic snail hexokinase are consistent with a less active enzyme | Littorina littorea | - |
2.7.1.1 | hepatopancreas | during anoxia, a reduction in the Km for glucose for hexokinase from the anoxic animal suggests a more active enzyme form | Littorina littorea | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.1 | ATP + D-glucose | - |
Littorina littorea | ADP + D-glucose 6-phosphate | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.1.1 | 190 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
2.7.1.1 | 210 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
2.7.1.1 | 230 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
2.7.1.1 | 230 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
2.7.1.1 | 240 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | NaCl | |
2.7.1.1 | 260 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | KCl | |
2.7.1.1 | 260 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | KCl | |
2.7.1.1 | 280 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | KCl | |
2.7.1.1 | 280 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | NaCl | |
2.7.1.1 | 280 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | KCl | |
2.7.1.1 | 290 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NaCl | |
2.7.1.1 | 300 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NaCl | |
2.7.1.1 | 990 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | Urea | |
2.7.1.1 | 1170 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | Urea | |
2.7.1.1 | 1310 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | Urea | |
2.7.1.1 | 1490 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | Urea |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.1 | physiological function | dephosphorylation and activation of hepatopancreas hexokinase during anoxia may allow for increased shunting of glucose-6-phosphate into the pentose phosphate pathway, thereby producing reducing equivalents of NADPH. The activation of endogenous protein kinase C and AMP-activated protein kinase increase the Km for glucose for anoxic hepatopancreas hexokinase to a value that is similar to the control Km for glucose. Stimulation of endogenous protein kinase C, protein kinase G, and Calcium/calmodulin activated protein kinase for foot muscle hexokinase increase the Km for ATP to a value similar to that seen for the anoxic enzyme form. In both tissues, activation of endogenous phosphatases reverses the effects of protein kinases | Littorina littorea |