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Literature summary extracted from

  • Ekuase, E.J.; Lehmler, H.J.; Robertson, L.W.; Duffel, M.W.
    Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1 (2014), Chem. Biol. Interact., 212, 56-64.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.2 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.2 3,3',4'-dihydroxy-4-monochlorobiphenyl
-
 Homo sapiens
2.8.2.2 4'-hydroxy-2',3,4-trichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl
-
 Homo sapiens
2.8.2.2 4'-hydroxy-2,3',4-trichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4'-hydroxy-2,3'-dichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4'-hydroxy-2,5-dichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4'-hydroxy-3,4-dichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4'-hydroxy-4-monochlorobiphenyl
-
 Homo sapiens
2.8.2.2 4-hydroxy-2',3,5-trichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4-hydroxy-2,4'-dichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4-hydroxy-3,3',5-trichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4-hydroxy-3,3'-dichlorobiphenyl
-
 Homo sapiens
2.8.2.2 4-hydroxy-3,5-dichlorobiphenyl
-
 Homo sapiens
2.8.2.2 5,3',4'-dihydroxy-2,3-dichlorobiphenyl
-
 Homo sapiens
2.8.2.2 6'-hydroxy-3,3'4-trichlorobiphenyl
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Homo sapiens Q06520
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.2
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylylsulfate + dehydroepiandrosterone
-
 Homo sapiens adenosine 3',5'-bisphosphate + dehydroepiandrosterone 3-sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 hydroxysteroid sulfotransferase
-
 Homo sapiens
2.8.2.2 SULT2A1
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.2 0.0006
-
 4'-hydroxy-2,3',4,5'-tetrachlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.0007
-
 4'-hydroxy-2,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.0008
-
 4-hydroxy-2',3,5-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.003
-
 4'-hydroxy-2',3,4-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.003
-
 4'-hydroxy-2,3',4-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.0034
-
 4-hydroxy-3,3',5-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.004
-
 4'-hydroxy-3,4-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.005
-
 4-hydroxy-2,4'-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.0054
-
 4'-hydroxy-2,3'-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.009
-
 6'-hydroxy-3,3'4-trichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.012
-
 4-hydroxy-3,3'-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.0135
-
 4-hydroxy-3,5-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.014
-
 5,3',4'-dihydroxy-2,3-dichlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.017
-
 4'-hydroxy-4-monochlorobiphenyl at pH 7.0 and 37°C Homo sapiens
2.8.2.2 0.032
-
 3,3',4'-dihydroxy-4-monochlorobiphenyl at pH 7.0 and 37°C Homo sapiens