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Literature summary extracted from

  • Fan, Y.; Yu, Y.; Jia, X.; Chen, X.; Shen, Y.
    Cloning, expression and medium optimization of validamycin glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of validoxylamine A to produce validamycin A using free resting cells (2013), Biores. Technol., 131, 13-20.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.338 expressed in Escherichia coli BL21(DE3) cells Streptomyces hygroscopicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.338 Co2+
-
 Streptomyces hygroscopicus
2.4.1.338 Cu2+
-
 Streptomyces hygroscopicus
2.4.1.338 Li+
-
 Streptomyces hygroscopicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.338 Ca2+ promotes enzyme activity Streptomyces hygroscopicus
2.4.1.338 Fe2+ promotes enzyme activity Streptomyces hygroscopicus
2.4.1.338 Mg2+ promotes enzyme activity Streptomyces hygroscopicus
2.4.1.338 Mn2+ promotes enzyme activity Streptomyces hygroscopicus
2.4.1.338 Zn2+ promotes enzyme activity Streptomyces hygroscopicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.338 47000
-
 x * 47000, SDS-PAGE Streptomyces hygroscopicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.338 UDP-alpha-D-glucose + validoxylamine A Streptomyces hygroscopicus
-
 UDP + validamycin A
-
 ?
2.4.1.338 UDP-alpha-D-glucose + validoxylamine A Streptomyces hygroscopicus 5008
-
 UDP + validamycin A
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.338 Streptomyces hygroscopicus
-
 variant Streptomyces hygroscopicus jinggangensis
-
2.4.1.338 Streptomyces hygroscopicus 5008
-
 variant Streptomyces hygroscopicus jinggangensis
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.338 UDP-alpha-D-glucose + validoxylamine A
-
 Streptomyces hygroscopicus UDP + validamycin A
-
 ?
2.4.1.338 UDP-alpha-D-glucose + validoxylamine A
-
 Streptomyces hygroscopicus 5008 UDP + validamycin A
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.338 ? x * 47000, SDS-PAGE Streptomyces hygroscopicus

Synonyms

EC Number Synonyms Comment Organism
2.4.1.338 valG
-
 Streptomyces hygroscopicus