EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.1 | (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one | - |
Homo sapiens | |
2.7.10.1 | (3Z)-3-[3-([1,4'-bipiperidine]-1'-carbonyl)-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one | - |
Homo sapiens | |
2.7.10.1 | (3Z)-5-fluoro-3-(2-methyl-3-[(2S)-2-[(pyrrolidin-1-yl)methyl]pyrrolidine-1-carbonyl]-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-1,3-dihydro-2H-indol-2-one | - |
Homo sapiens | |
2.7.10.1 | (3Z)-5-fluoro-3-[2-methyl-3-(morpholine-4-carbonyl)-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-1,3-dihydro-2H-indol-2-one | - |
Homo sapiens | |
2.7.10.1 | (3Z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1H-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2H-indol-2-one | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(morpholin-4-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(piperidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyridin-2-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyrrolidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(2-hydroxyethyl)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-7-(4-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-[[(diethylamino)oxy]sulfinyl]-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(diethylamino)ethyl]-7-(7-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[2-(dimethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[3-(diethylamino)-2-hydroxypropyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | (7Z)-N-[3-(diethylamino)propyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | 3-(2,4-dimethyl-5-[(Z)-[2-oxo-5-(2-phenylhydrazinecarbonyl)-1,2-dihydro-3H-indol-3-ylidene]methyl]-1H-pyrrol-3-yl)propanoic acid | - |
Homo sapiens | |
2.7.10.1 | 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | - |
Homo sapiens | |
2.7.10.1 | 3-[2-[(Z)-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-4,5,6,7-tetrahydro-1H-indol-3-yl]propanoic acid | - |
Homo sapiens | |
2.7.10.1 | 3-[4-methyl-2-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | - |
Homo sapiens | |
2.7.10.1 | 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(morpholin-4-yl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide | - |
Homo sapiens | |
2.7.10.1 | axitinib | - |
Homo sapiens | |
2.7.10.1 | methyl (3Z)-3-(3-[[2-(diethylamino)ethyl]carbamoyl]-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylate | - |
Homo sapiens | |
2.7.10.1 | N-[(3Z)-2-oxo-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-6-yl]-N'-phenylurea | - |
Homo sapiens | |
2.7.10.1 | regorafenib | - |
Homo sapiens | |
2.7.10.1 | sorafenib | - |
Homo sapiens | |
2.7.10.1 | sunitinib | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.1 | ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.10.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.10.1 | BGC823 cell | - |
Homo sapiens | - |
2.7.10.1 | BxPC-3 cell | - |
Homo sapiens | - |
2.7.10.1 | Hep-G2 cell | - |
Homo sapiens | - |
2.7.10.1 | HT-29 cell | - |
Homo sapiens | - |
2.7.10.1 | T-24 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.1 | ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.10.1 | c-kit | - |
Homo sapiens |
2.7.10.1 | PDGFR-beta | - |
Homo sapiens |
2.7.10.1 | RTK | - |
Homo sapiens |
2.7.10.1 | VEGFR-2 | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.10.1 | 0.000001 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000011 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(2-hydroxyethyl)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000011 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (3Z)-5-fluoro-3-[2-methyl-3-(morpholine-4-carbonyl)-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0000014 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(2-hydroxyethyl)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000016 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(morpholin-4-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.000002 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(morpholin-4-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000021 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (3Z)-5-fluoro-3-[2-methyl-3-(morpholine-4-carbonyl)-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0000023 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000023 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000023 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000024 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000025 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[3-(diethylamino)-2-hydroxypropyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000026 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000027 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000027 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[3-(diethylamino)propyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.000003 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(dimethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000038 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000039 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.000004 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | sunitinib | |
2.7.10.1 | 0.0000041 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000041 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[3-(diethylamino)-2-hydroxypropyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000043 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(piperidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000057 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000058 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(piperidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000066 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(dimethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000069 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000074 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyrrolidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000076 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000078 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (3Z)-3-[3-([1,4'-bipiperidine]-1'-carbonyl)-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.000008 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (3Z)-3-[3-([1,4'-bipiperidine]-1'-carbonyl)-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0000085 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (3Z)-5-fluoro-3-(2-methyl-3-[(2S)-2-[(pyrrolidin-1-yl)methyl]pyrrolidine-1-carbonyl]-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0000089 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | sunitinib | |
2.7.10.1 | 0.0000094 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000097 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyrrolidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000099 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[3-(diethylamino)propyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000101 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000106 | - |
PDGFR, pH and temperature not specified in the publication | Homo sapiens | sunitinib | |
2.7.10.1 | 0.0000107 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000114 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyridin-2-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000118 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (3Z)-5-fluoro-3-(2-methyl-3-[(2S)-2-[(pyrrolidin-1-yl)methyl]pyrrolidine-1-carbonyl]-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0000121 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-[2-(diethylamino)ethyl]-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000127 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(2-hydroxyethyl)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000132 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(morpholin-4-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000133 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.000015 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(4-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000156 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.000018 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000193 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[3-(diethylamino)-2-hydroxypropyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000194 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(piperidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000213 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[3-(diethylamino)propyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000227 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(dimethylamino)ethyl]-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000246 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000257 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000355 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000377 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyridin-2-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000401 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (3Z)-5-fluoro-3-[2-methyl-3-(morpholine-4-carbonyl)-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0000407 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (3Z)-3-[3-([1,4'-bipiperidine]-1'-carbonyl)-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0000416 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyrrolidin-1-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000431 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(4-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000621 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(4-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000648 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0000703 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | methyl (3Z)-3-(3-[[2-(diethylamino)ethyl]carbamoyl]-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylate | |
2.7.10.1 | 0.0000899 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-2-methyl-7-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0001014 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0001124 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(7-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0001184 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (3Z)-5-fluoro-3-(2-methyl-3-[(2S)-2-[(pyrrolidin-1-yl)methyl]pyrrolidine-1-carbonyl]-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-1,3-dihydro-2H-indol-2-one | |
2.7.10.1 | 0.0001606 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-7-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-N-[2-(pyridin-2-yl)ethyl]-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0001672 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | methyl (3Z)-3-(3-[[2-(diethylamino)ethyl]carbamoyl]-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylate | |
2.7.10.1 | 0.0001808 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(7-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0002557 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | methyl (3Z)-3-(3-[[2-(diethylamino)ethyl]carbamoyl]-2-methyl-1,4,5,6-tetrahydro-7H-indol-7-ylidene)-2-oxo-2,3-dihydro-1H-indole-5-carboxylate | |
2.7.10.1 | 0.0002603 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(7-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0003303 | - |
VEGFR-2, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-[[(diethylamino)oxy]sulfinyl]-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0003957 | - |
PDGFR-beta, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-[[(diethylamino)oxy]sulfinyl]-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide | |
2.7.10.1 | 0.0003976 | - |
c-Kit, pH and temperature not specified in the publication | Homo sapiens | (7Z)-N-[2-(diethylamino)ethyl]-7-(5-[[(diethylamino)oxy]sulfinyl]-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-methyl-4,5,6,7-tetrahydro-1H-indole-3-carboxamide |