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Literature summary extracted from

  • Takahashi, Y.; Kubota, T.; Yamamoto, S.; Kobayashi, J.
    Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2 (2013), Bioorg. Med. Chem. Lett., 23, 117-118.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 N-(4-hydroxy-5-[(2E)-3-methyl-5-[(1R,2S)-1,2,3-trimethylcyclohex-3-en-1-yl]pent-2-en-1-yl]-3,6-dioxocyclohexa-1,4-dien-1-yl)glycine IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.079 mg/ml for HER3 Homo sapiens
2.7.10.1 N-(5-[(2E)-5-[(1R)-1,3-dimethyl-2-methylidenecyclohex-3-en-1-yl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-serine IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.022 mg/ml for HER3 Homo sapiens
2.7.10.1 N-(5-[(2E)-5-[(1R)-1,3-dimethyl-2-methylidenecyclohex-3-en-1-yl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-threonine IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.027 mg/ml for HER3 Homo sapiens
2.7.10.1 N-(5-[(2E)-5-[(1R,3R)-1,3-dimethyl-2-methylidenecyclohexyl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-serine IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.018 mg/ml for HER3 Homo sapiens
2.7.10.1 N-(5-[(2E)-5-[(1R,3R)-1,3-dimethyl-2-methylidenecyclohexyl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-D-threonine IC50 of more than 0.2 mg/ml for EGFR, IC50 of 0.19 mg/ml for HER3 Homo sapiens
2.7.10.1 N-(5-[(2E)-5-[(1R,3R)-1,3-dimethyl-2-methylidenecyclohexyl]-3-methylpent-2-en-1-yl]-4-hydroxy-3,6-dioxocyclohexa-1,4-dien-1-yl)glycine IC50 of 0.197 mg/ml for EGFR, IC50 of 0.125 mg/ml for HER2 Homo sapiens
2.7.10.1 nakijiquinone C IC50 of 0.125 mg/ml for EGFR, IC50 of 0.103 mg/ml for HER2 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 Egfr
-
 Homo sapiens
2.7.10.1 epidermal growth factor receptor
-
 Homo sapiens
2.7.10.1 HER2
-
 Homo sapiens
2.7.10.1 human epidermal growth factor receptor2
-
 Homo sapiens
2.7.10.1 RTK
-
 Homo sapiens