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Literature summary extracted from

  • van Kuilenburg, A.B.; Meinsma, R.
    The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma (2016), Biochim. Biophys. Acta, 1862, 1504-1512.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.48 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.48 cytosol
-
 Homo sapiens 5829
-
2.7.1.48 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.48 ATP + uridine Homo sapiens
-
 ADP + UMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.48 Homo sapiens Q9BZX2
-
-
2.7.1.48 Homo sapiens Q9HA47
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.48 Ni-NTA agarose column chromatography and Sephadex G25 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.48 IMR-32 cell
-
 Homo sapiens
-
2.7.1.48 neuroblastoma cell
-
 Homo sapiens
-
2.7.1.48 SHEP-21N cell
-
 Homo sapiens
-
2.7.1.48 SJNB-10 cell
-
 Homo sapiens
-
2.7.1.48 SJNB-8 cell
-
 Homo sapiens
-
2.7.1.48 SKNAS cell
-
 Homo sapiens
-
2.7.1.48 SKNBE cell
-
 Homo sapiens
-
2.7.1.48 SKNFI cell
-
 Homo sapiens
-
2.7.1.48 SKNSH cell
-
 Homo sapiens
-
2.7.1.48 SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.48 ATP + uridine
-
 Homo sapiens ADP + UMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.48 UCK1 isoform Homo sapiens
2.7.1.48 UCK2 isoform Homo sapiens
2.7.1.48 uridine-cytidine kinase
-
 Homo sapiens