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Literature summary extracted from

  • Baldwin, G.S.; Lio, D.S.; Ferrand, A.; Catimel, B.; Shehan, B.P.; Norton, R.S.; Cheng, H.C.
    Activation of Src family tyrosine kinases by ferric ions (2014), Biochim. Biophys. Acta, 1844, 487-496.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 Fe3+ Lyn or Hck kinases in the unphosphorylated active state are significantly inhibited by Fe3+ ion Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Fe3+ when Lyn or Hck kinases, which have been stabilised in the inactive state by phosphorylation of the C-terminal regulatory tyrosine, are incubated with Fe3+ ions, a significant enhancement of kinase activity is observed Homo sapiens
2.7.10.2 additional information not activated by Ca2+, Zn2+ or Bi3+ ions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + [[Lys19]Cdc2-(6-20) peptide]-L-tyrosine i.e. KVEKIGEGTYGVVKK Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 HCK
-
 Homo sapiens
2.7.10.2 Lyn
-
 Homo sapiens
2.7.10.2 SFK
-
 Homo sapiens