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Literature summary extracted from

  • Moberg, A.; Zander Balderud, L.; Hansson, E.; Boyd, H.
    Assessing HTS performance using bioassay ontology: screening and analysis of a bacterial phospho-N-acetylmuramoyl-pentapeptide translocase campaign (2014), Assay Drug Dev. Technol., 12, 506-513.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.8.13 analysis the enzyme is an attractive antibacterial drug target involved in peptidoglycan synthesis Bacillus subtilis
2.7.8.13 synthesis the enzyme is an attractive antibacterial drug target involved in peptidoglycan synthesis Bacillus subtilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.13 EDTA complete inhibition at 2 mM Bacillus subtilis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.8.13 Mg2+ required Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.13 Bacillus subtilis Q03521 gene mraY
-
2.7.8.13 Bacillus subtilis 168 Q03521 gene mraY
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.13 additional information assay method development for high-throughput screening assays and metadata annotation, overview Bacillus subtilis ?
-
 ?
2.7.8.13 additional information assay method development for high-throughput screening assays and metadata annotation, overview Bacillus subtilis 168 ?
-
 ?
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
 Bacillus subtilis UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
 Bacillus subtilis 168 UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.13 MraY
-
 Bacillus subtilis
2.7.8.13 phospho-N-acetylmuramoyl-pentapeptide translocase
-
 Bacillus subtilis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.13 22
-
 assay at room temperature Bacillus subtilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.13 7.5
-
 assay at Bacillus subtilis