Data extracted from this reference:
Cloned(Commentary)
2.7.1.74
expressed in Escherichia coli BL21 C41(DE3) cells
Homo sapiens
Crystallization (Commentary)
2.7.1.74
in complex with inhibitors and UDP, hanging drop vapor diffusion method, using 0.9-1.5 M trisodium citrate dehydrate and 25 mM HEPES pH 7.5
Homo sapiens
Inhibitors
2.7.1.74
2-[(2[-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
2.7.1.74
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
2.7.1.74
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
2.7.1.74
2-[([5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
Localization
2.7.1.74
cytosol
Homo sapiens
5829
Natural Substrates/ Products (Substrates)
2.7.1.74
ATP + deoxycytidine
Homo sapiens
ADP + dCMP
?
2.7.1.74
UTP + deoxycytidine
Homo sapiens
UDP + dCMP
?
Organism
2.7.1.74
Homo sapiens
P27707
Purification (Commentary)
2.7.1.74
HisTrap nickel-affinity column chromatography and S-200 gel filtration
Homo sapiens
Substrates and Products (Substrate)
2.7.1.74
ATP + clofarabine
737347
Homo sapiens
ADP + clofarabine 5'-phosphate
?
2.7.1.74
ATP + deoxyadenosine
737347
Homo sapiens
ADP + dAMP
?
2.7.1.74
ATP + deoxycytidine
737347
Homo sapiens
ADP + dCMP
?
2.7.1.74
ATP + deoxyguanosine
737347
Homo sapiens
ADP + dGMP
?
2.7.1.74
ATP + fludarabine
737347
Homo sapiens
ADP + fludarabine 5'-phosphate
?
2.7.1.74
ATP + gemcitabine
737347
Homo sapiens
ADP + gemcitabine 5'-phosphate
?
2.7.1.74
ATP + lamivudine
737347
Homo sapiens
ADP + lamivudine 5'-phosphate
?
2.7.1.74
UTP + deoxyadenosine
737347
Homo sapiens
UDP + dAMP
?
2.7.1.74
UTP + deoxycytidine
737347
Homo sapiens
UDP + dCMP
?
2.7.1.74
UTP + deoxyguanosine
737347
Homo sapiens
UDP + dGMP
?
Subunits
2.7.1.74
homodimer
Homo sapiens
Synonyms
2.7.1.74
dCK
Homo sapiens
IC50 Value
2.7.1.74
0.0000167
pH and temperature not specified in the publication
Homo sapiens
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
2.7.1.74
0.0000227
pH and temperature not specified in the publication
Homo sapiens
2-[([5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
2.7.1.74
0.0000263
pH and temperature not specified in the publication
Homo sapiens
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
2.7.1.74
0.0007457
pH and temperature not specified in the publication
Homo sapiens
2-[(2[-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Cloned(Commentary) (protein specific)
2.7.1.74
expressed in Escherichia coli BL21 C41(DE3) cells
Homo sapiens
Crystallization (Commentary) (protein specific)
2.7.1.74
in complex with inhibitors and UDP, hanging drop vapor diffusion method, using 0.9-1.5 M trisodium citrate dehydrate and 25 mM HEPES pH 7.5
Homo sapiens
IC50 Value (protein specific)
2.7.1.74
0.0000167
pH and temperature not specified in the publication
Homo sapiens
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
2.7.1.74
0.0000227
pH and temperature not specified in the publication
Homo sapiens
2-[([5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
2.7.1.74
0.0000263
pH and temperature not specified in the publication
Homo sapiens
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
2.7.1.74
0.0007457
pH and temperature not specified in the publication
Homo sapiens
2-[(2[-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Inhibitors (protein specific)
2.7.1.74
2-[(2[-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
2.7.1.74
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
2.7.1.74
2-[([2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-propyl-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
2.7.1.74
2-[([5-ethyl-2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-1,3-thiazol-4-yl]methyl)sulfanyl]pyrimidine-4,6-diamine
Homo sapiens
Localization (protein specific)
2.7.1.74
cytosol
Homo sapiens
5829
Natural Substrates/ Products (Substrates) (protein specific)
2.7.1.74
ATP + deoxycytidine
Homo sapiens
ADP + dCMP
?
2.7.1.74
UTP + deoxycytidine
Homo sapiens
UDP + dCMP
?
Purification (Commentary) (protein specific)
2.7.1.74
HisTrap nickel-affinity column chromatography and S-200 gel filtration
Homo sapiens
Substrates and Products (Substrate) (protein specific)
2.7.1.74
ATP + clofarabine
737347
Homo sapiens
ADP + clofarabine 5'-phosphate
?
2.7.1.74
ATP + deoxyadenosine
737347
Homo sapiens
ADP + dAMP
?
2.7.1.74
ATP + deoxycytidine
737347
Homo sapiens
ADP + dCMP
?
2.7.1.74
ATP + deoxyguanosine
737347
Homo sapiens
ADP + dGMP
?
2.7.1.74
ATP + fludarabine
737347
Homo sapiens
ADP + fludarabine 5'-phosphate
?
2.7.1.74
ATP + gemcitabine
737347
Homo sapiens
ADP + gemcitabine 5'-phosphate
?
2.7.1.74
ATP + lamivudine
737347
Homo sapiens
ADP + lamivudine 5'-phosphate
?
2.7.1.74
UTP + deoxyadenosine
737347
Homo sapiens
UDP + dAMP
?
2.7.1.74
UTP + deoxycytidine
737347
Homo sapiens
UDP + dCMP
?
2.7.1.74
UTP + deoxyguanosine
737347
Homo sapiens
UDP + dGMP
?
Subunits (protein specific)
2.7.1.74
homodimer
Homo sapiens