BRENDA - Enzyme Database show

Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase

Xu, T.Y.; Zhang, S.L.; Dong, G.Q.; Liu, X.Z.; Wang, X.; Lv, X.Q.; Qian, Q.J.; Zhang, R.Y.; Sheng, C.Q.; Miao, C.Y.; Sci. Rep. 5, 10043 (2015)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
(1Z)-N'-(benzoyloxy)-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanimidamide
-
Homo sapiens
2.4.2.12
(2R,2'R)-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-2,2',3,3'-tetrahydro-4H,4'H-[3,8'-bi-1-benzopyran]-4,4'-dione
-
Homo sapiens
2.4.2.12
1-(pyridin-3-ylmethyl)-3-[4-(pyrrolidin-1-ylsulfonyl)phenyl]thiourea
-
Homo sapiens
2.4.2.12
1-[3-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
potent inhibitor
Homo sapiens
2.4.2.12
1-[4-(morpholin-4-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-(piperazin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylcarbonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)guanidine
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)urea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)guanidine
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
4-chloro-N-[(5-[[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]sulfamoyl]thiophen-2-yl)methyl]benzamide
-
Homo sapiens
2.4.2.12
ethyl [(E)-[4-(piperidine-1-sulfonyl)anilino][[(pyridin-3-yl)methyl]amino]methylidene]carbamate
-
Homo sapiens
2.4.2.12
N-(4-[4-[(1H-benzimidazol-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2,6-difluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(3-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(3-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(3-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-aminophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-bromophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-butylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-nitrophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(furan-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(furan-3-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(naphthalen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-benzyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
-
Homo sapiens
2.4.2.12
N-phenyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-4-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-[4-[4-(pyridin-2-yl)piperazine-1-sulfonyl]phenyl]thiourea
-
Homo sapiens
2.4.2.12
N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
-
Homo sapiens
2.4.2.12
N-[4-(4-acetylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-[4-(4-benzylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-[4-(4-cyclohexylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-[4-[(4E)-4-(2,3-dimethoxybenzylidene)-5-oxo-4,5-dihydro-1,3-oxazol-2-yl]phenyl]thiophene-2-carboxamide
-
Homo sapiens
2.4.2.12
N-[4-[4-(4-methylphenyl)piperazine-1-sulfonyl]phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
tert-butyl 4-[4-([[(pyridin-3-yl)methyl]carbamothioyl]amino)benzene-1-sulfonyl]piperazine-1-carboxylate
-
Homo sapiens
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.4.2.12
55000
-
x * 55000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.12
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
95-D cell
-
Homo sapiens
-
2.4.2.12
A-2780 cell
-
Homo sapiens
-
2.4.2.12
Hep-G2 cell
-
Homo sapiens
-
2.4.2.12
U2OS cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
737247
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
2.4.2.12
?
x * 55000, SDS-PAGE
Homo sapiens
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.4.2.12
0.0000009
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-(4-benzylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000089
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(3-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000098
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.0000099
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2,6-difluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000105
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.000012
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000123
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000124
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000126
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(3-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000137
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000137
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-4-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.000014
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(1H-benzimidazol-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000142
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-(4-cyclohexylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000154
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-[4-(4-methylphenyl)piperazine-1-sulfonyl]phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000157
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000168
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(3-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000177
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-[4-[4-(pyridin-2-yl)piperazine-1-sulfonyl]phenyl]thiourea
2.4.2.12
0.0000191
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(furan-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000196
-
at pH 7.5 and 37°C
Homo sapiens
N-benzyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
2.4.2.12
0.0000197
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-nitrophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000199
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-aminophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000201
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea
2.4.2.12
0.0000217
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(morpholin-4-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000217
-
at pH 7.5 and 37°C
Homo sapiens
tert-butyl 4-[4-([[(pyridin-3-yl)methyl]carbamothioyl]amino)benzene-1-sulfonyl]piperazine-1-carboxylate
2.4.2.12
0.000022
-
at pH 7.5 and 37°C
Homo sapiens
N-phenyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
2.4.2.12
0.0000225
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.0000237
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
2.4.2.12
0.0000242
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-bromophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000295
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(naphthalen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000369
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
2.4.2.12
0.0000388
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.0000405
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-(4-acetylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000422
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-ylcarbonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000439
-
at pH 7.5 and 37°C
Homo sapiens
1-(pyridin-3-ylmethyl)-3-[4-(pyrrolidin-1-ylsulfonyl)phenyl]thiourea
2.4.2.12
0.0000487
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(furan-3-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000798
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-butylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000845
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperazin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000964
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000989
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)urea
2.4.2.12
0.000765
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)guanidine
2.4.2.12
0.00987
-
at pH 7.5 and 37°C
Homo sapiens
1-[3-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.01453
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)guanidine
2.4.2.12
0.149
-
at pH 7.5 and 37°C
Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
2.4.2.12
0.166
-
at pH 7.5 and 37°C
Homo sapiens
ethyl [(E)-[4-(piperidine-1-sulfonyl)anilino][[(pyridin-3-yl)methyl]amino]methylidene]carbamate
2.4.2.12
0.504
-
at pH 7.5 and 37°C
Homo sapiens
(2R,2'R)-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-2,2',3,3'-tetrahydro-4H,4'H-[3,8'-bi-1-benzopyran]-4,4'-dione
2.4.2.12
0.855
-
at pH 7.5 and 37°C
Homo sapiens
(1Z)-N'-(benzoyloxy)-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanimidamide
2.4.2.12
4.162
-
at pH 7.5 and 37°C
Homo sapiens
4-chloro-N-[(5-[[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]sulfamoyl]thiophen-2-yl)methyl]benzamide
2.4.2.12
6.443
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-[(4E)-4-(2,3-dimethoxybenzylidene)-5-oxo-4,5-dihydro-1,3-oxazol-2-yl]phenyl]thiophene-2-carboxamide
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.4.2.12
0.0000009
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-(4-benzylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000089
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(3-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000098
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.0000099
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2,6-difluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000105
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.000012
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000123
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000124
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000126
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(3-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000137
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000137
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-4-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.000014
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(1H-benzimidazol-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000142
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-(4-cyclohexylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000154
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-[4-(4-methylphenyl)piperazine-1-sulfonyl]phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000157
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(2-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000168
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(3-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000177
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-[4-[4-(pyridin-2-yl)piperazine-1-sulfonyl]phenyl]thiourea
2.4.2.12
0.0000191
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(furan-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000196
-
at pH 7.5 and 37°C
Homo sapiens
N-benzyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
2.4.2.12
0.0000197
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-nitrophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000199
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-aminophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000201
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea
2.4.2.12
0.0000217
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(morpholin-4-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000217
-
at pH 7.5 and 37°C
Homo sapiens
tert-butyl 4-[4-([[(pyridin-3-yl)methyl]carbamothioyl]amino)benzene-1-sulfonyl]piperazine-1-carboxylate
2.4.2.12
0.000022
-
at pH 7.5 and 37°C
Homo sapiens
N-phenyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
2.4.2.12
0.0000225
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.0000237
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
2.4.2.12
0.0000242
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-bromophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000295
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(naphthalen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000369
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
2.4.2.12
0.0000388
-
at pH 7.5 and 37°C
Homo sapiens
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
2.4.2.12
0.0000405
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-(4-acetylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000422
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-ylcarbonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000439
-
at pH 7.5 and 37°C
Homo sapiens
1-(pyridin-3-ylmethyl)-3-[4-(pyrrolidin-1-ylsulfonyl)phenyl]thiourea
2.4.2.12
0.0000487
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(furan-3-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000798
-
at pH 7.5 and 37°C
Homo sapiens
N-(4-[4-[(4-butylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
2.4.2.12
0.0000845
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperazin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000964
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.0000989
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)urea
2.4.2.12
0.000765
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)guanidine
2.4.2.12
0.00987
-
at pH 7.5 and 37°C
Homo sapiens
1-[3-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
2.4.2.12
0.01453
-
at pH 7.5 and 37°C
Homo sapiens
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)guanidine
2.4.2.12
0.149
-
at pH 7.5 and 37°C
Homo sapiens
N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
2.4.2.12
0.166
-
at pH 7.5 and 37°C
Homo sapiens
ethyl [(E)-[4-(piperidine-1-sulfonyl)anilino][[(pyridin-3-yl)methyl]amino]methylidene]carbamate
2.4.2.12
0.504
-
at pH 7.5 and 37°C
Homo sapiens
(2R,2'R)-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-2,2',3,3'-tetrahydro-4H,4'H-[3,8'-bi-1-benzopyran]-4,4'-dione
2.4.2.12
0.855
-
at pH 7.5 and 37°C
Homo sapiens
(1Z)-N'-(benzoyloxy)-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanimidamide
2.4.2.12
4.162
-
at pH 7.5 and 37°C
Homo sapiens
4-chloro-N-[(5-[[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]sulfamoyl]thiophen-2-yl)methyl]benzamide
2.4.2.12
6.443
-
at pH 7.5 and 37°C
Homo sapiens
N-[4-[(4E)-4-(2,3-dimethoxybenzylidene)-5-oxo-4,5-dihydro-1,3-oxazol-2-yl]phenyl]thiophene-2-carboxamide
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.12
(1Z)-N'-(benzoyloxy)-3-(2-oxo-1,3-benzoxazol-3(2H)-yl)propanimidamide
-
Homo sapiens
2.4.2.12
(2R,2'R)-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-2,2',3,3'-tetrahydro-4H,4'H-[3,8'-bi-1-benzopyran]-4,4'-dione
-
Homo sapiens
2.4.2.12
1-(pyridin-3-ylmethyl)-3-[4-(pyrrolidin-1-ylsulfonyl)phenyl]thiourea
-
Homo sapiens
2.4.2.12
1-[3-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
potent inhibitor
Homo sapiens
2.4.2.12
1-[4-(morpholin-4-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-(piperazin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylcarbonyl)phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)guanidine
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-yloxy)phenyl]-3-(pyridin-3-ylmethyl)urea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)guanidine
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea
-
Homo sapiens
2.4.2.12
1-[4-(piperidin-1-ylsulfonyl)phenyl]-3-(pyridin-4-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
1-[4-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-3-(pyridin-3-ylmethyl)thiourea
-
Homo sapiens
2.4.2.12
4-chloro-N-[(5-[[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]sulfamoyl]thiophen-2-yl)methyl]benzamide
-
Homo sapiens
2.4.2.12
ethyl [(E)-[4-(piperidine-1-sulfonyl)anilino][[(pyridin-3-yl)methyl]amino]methylidene]carbamate
-
Homo sapiens
2.4.2.12
N-(4-[4-[(1H-benzimidazol-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2,6-difluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(2-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(3-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(3-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(3-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-aminophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-bromophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-butylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-chlorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-fluorophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-methylphenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(4-nitrophenyl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(furan-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(furan-3-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-(4-[4-[(naphthalen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-benzyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
-
Homo sapiens
2.4.2.12
N-phenyl-4-[[(pyridin-3-ylmethyl)carbamothioyl]amino]benzenesulfonamide
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(pyridin-4-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-2-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-(4-[4-[(thiophen-3-yl)methyl]piperazine-1-sulfonyl]phenyl)thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethoxy)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-[4-(4-[[4-(trifluoromethyl)phenyl]methyl]piperazine-1-sulfonyl)phenyl]thiourea
-
Homo sapiens
2.4.2.12
N-[(pyridin-3-yl)methyl]-N'-[4-[4-(pyridin-2-yl)piperazine-1-sulfonyl]phenyl]thiourea
-
Homo sapiens
2.4.2.12
N-[2-(3,4-dimethoxyphenyl)ethyl]-1-benzothiophene-2-carboxamide
-
Homo sapiens
2.4.2.12
N-[4-(4-acetylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-[4-(4-benzylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-[4-(4-cyclohexylpiperazine-1-sulfonyl)phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
N-[4-[(4E)-4-(2,3-dimethoxybenzylidene)-5-oxo-4,5-dihydro-1,3-oxazol-2-yl]phenyl]thiophene-2-carboxamide
-
Homo sapiens
2.4.2.12
N-[4-[4-(4-methylphenyl)piperazine-1-sulfonyl]phenyl]-N'-[(pyridin-3-yl)methyl]thiourea
-
Homo sapiens
2.4.2.12
tert-butyl 4-[4-([[(pyridin-3-yl)methyl]carbamothioyl]amino)benzene-1-sulfonyl]piperazine-1-carboxylate
-
Homo sapiens
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
2.4.2.12
55000
-
x * 55000, SDS-PAGE
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.12
95-D cell
-
Homo sapiens
-
2.4.2.12
A-2780 cell
-
Homo sapiens
-
2.4.2.12
Hep-G2 cell
-
Homo sapiens
-
2.4.2.12
U2OS cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
737247
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.4.2.12
?
x * 55000, SDS-PAGE
Homo sapiens